| Project/Area Number |
20780042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied entomology
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
ANBUTSU Hisashi National Institute of Advanced Industrial Science and Technology, 生物プロセス研究部門, 研究グループ付 (30392583)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 共生細菌 / ショウジョウバエ / スピロプラズマ / ファージ / 生殖操作 / 雄殺し / 免疫機構 / 性比 / P58遺伝子ファミリー / 抗菌タンパク質 / 分子機構 |
|---|
| Research Abstract |
This study has been conducted using the endosymbiotic system consists of host insects, Drosophila fruit flies, and symbiotic bacteria, Spiroplasma, which cause "male killing" on its hosts. From the three Spiroplasma strains, genome sequences of their phages were identified and characterized. It was shown that Spiroplasma infections neither induced nor suppressed the systemic immune response of the host. In addition, it was also determined that the male-killing Spiroplasma is capable of suppressing the constitutive immune response and is resistant to mounted immune attacks. Sixteen insertion lines, which showed extremely male-biased sex ratio, have been obtained and the possible causative genes have been identified.
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