| Project/Area Number |
20780055
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
ZENDO Takeshi Kyushu University, 大学院・農学研究院, 助教 (50380556)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 微生物機能 / 乳酸菌 / 抗菌ペプチド / バクテリオシン |
|---|
| Research Abstract |
The structures of various novel antimicrobial peptides, bacteriocins, from lactic acid bacteria were determined. One of the novel bacteriocins, lactocyclicin Q, is a cyclic peptide whose N- and C-terminals are bound with a peptide bond. Lacticin Q exerts antimicrobial activity via huge pore formation on bacterial cell membrane that causes leakage of cellular components such as ATP and small proteins. Since the actions of lacticin Q and lipids accords with the characteristics of Toroidal Pore model, the action mechanism of lacticin Q was termed Huge Toroidal Pore model .
|
