Novel antibiotic compounds and its corresponding genes isolated from Rhodococcus erythropolis strains

• Project/Area Number: 20780067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied microbiology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: KITAGAWA Wataru National Institute of Advanced Industrial Science and Technology, ゲノムファクトリー研究部門, 研究員 (60415669)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 抗生物質生産 / Rhodococcus / antibiotics / diversity / 応用微生物 / 抗生物質

Research Abstract

ロドコッカス属細菌に多数の抗生物質生産菌が存在することを示し、特にロドコッカスエリスロポリス(Rhodococcus erythropolis)に多くの活性株が存在することを明らかにした。またR. erythropolis JCM 6824から、グラム陽性菌に対し非常に高い活性を示す新規の抗生物質aurachin REを発見し、構造決定を行った。さらにこの生合成に関わる遺伝子も単離した。これら抗生物質、遺伝子はいずれもRhodococcus属由来として初めての報告である。さらにR. erythropolis DSM 11397、R. erythropolis JCM 2895の各株からもそれぞれ新規の抗生物質、抗菌タンパクを発見した。

Research Products

• [Journal Article] Phylogenetic Analysis of Rhodococcus erythropolis Based on the Variation of Ribosomal Proteins as Observed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry without Using Genome Information. (2009)
  • Author(s): Teramoto, K., Kitagawa, W., Sato, H., Torimura, M., Tamura, T., Tao, H.
  • Journal Title: J. Biosci. Bioeng. 108(4) Pages: 348-353
  • NAID: 110007465832
• [Journal Article] Phylogenetic Analysis of Rhodococcus erythropolis Based on the Variation of Ribosomal Proteins as Observed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry without Using Genome Information (2009)
  • Author(s): 寺本華奈江
  • Journal Title: Journal of Bioscience and Bioengineering 108 Pages: 348-353
  • Peer Reviewed
• [Journal Article] A Quinoline Antibiotic from Rhodococcus erythropolis JCM 6824. (2008)
  • Author(s): Kitagawa, W., Tamura, T.
  • Journal Title: J. Antibiot. 61(11) Pages: 680-682
  • NAID: 10024824901
• [Journal Article] Three types of antibiotics produced from Rhodococcus erythropolis strains. (2008)
  • Author(s): Kitagawa, W., Tamura, T.
  • Journal Title: Microbes & Environ. 23(2) Pages: 167-171
  • NAID: 110006684369
• [Journal Article] Three Types of Antibiotics Produced from Rhodococcus erythropolis Strains (2008)
  • Author(s): 北川 航
  • Journal Title: Microbes and Environments 23-2 Pages: 167-171
  • NAID: 110006684369
  • Peer Reviewed
• [Journal Article] A quinoline antibiotic from Rhodococcus erythropolis JCM 6824 (2008)
  • Author(s): 北川 航
  • Journal Title: Journal of Antibiotics 61-11 Pages: 680-682
  • NAID: 10024824901
  • Peer Reviewed
• [Presentation] Rhodococcus erythropolisが生産する3種の抗菌物質と生合成遺伝子解析 (2009)
  • Author(s): 北川航、田村具博
  • Organizer: 日本放線菌学会大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-07-17
• [Presentation] Rhodococcus erythropohsが生産する3種の抗菌物質と生合成遺伝子解析2009/07/17 (2009)
  • Author(s): 北川航
  • Organizer: 日本放線菌学会大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-07-17
• [Presentation] 抗菌活性を有するRhodococcus erythropolisの多様性 (2008)
  • Author(s): 北川航、田村具博、寺本華奈江(日本電子)、佐藤浩昭、孫麗 偉、鳥村政基、田尾博明
  • Organizer: 日本微生物生態学会第24回大会
  • Place of Presentation: 札幌
  • Year and Date: 2008-11-26
• [Presentation] 抗菌活性を有するRhodococcus erythropolisの多様性 (2008)
  • Author(s): 北川 航
  • Organizer: 日本微生物生態学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-11-26
• [Presentation] Intraspecies competition among antibiotic-producing Rhodococcus erythropolis strains (2008)
  • Author(s): 北川航、田村具博
  • Organizer: 放線菌ゲノム生物学に関する日英ワークショップ
  • Place of Presentation: 東京市ヶ谷
  • Year and Date: 2008-10-31
• [Presentation] Intraspecies competition among antibiotic-producing Rhodococcus erythropolis strains (2008)
  • Author(s): 北川 航
  • Organizer: 放線菌ゲノム生物学に関する日英ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2008-10-31
• [Presentation] THREE GROUPS OF ANTIBIOTIC-PRODUCING RHODOCOCCUS ERYTHROPOLIS (2008)
  • Author(s): 北川航、田村具 博
  • Organizer: 国際微生物生態学会(ISME)
  • Place of Presentation: ケアンズ
  • Year and Date: 2008-08-21
• [Presentation] Three groups of antibiotic-producing Rhodococcus erythropolis (2008)
  • Author(s): 北川 航
  • Organizer: 国際微生物生態学会(ISME)
  • Place of Presentation: ケアンズ
  • Year and Date: 2008-08-21
• [Remarks]
  • URL: http://unit.aist.go.jp/rigb/gf-ppt/index.html
• [Remarks]
  • URL: http://unit.aist.go.jp/rigb/gf-ppt/index.html