Characterization of novel exercise factors in skeletal muscle

• Project/Area Number: 20780071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied biochemistry
• Research Institution: The University of Tokyo
• Principal Investigator: NEDACHI Taku The University of Tokyo, 大学院・農学生命科学研究科, 特任研究員 (50375200)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 動物細胞 / 運動 / 分泌因子 / シグナル伝達 / 伸展

Research Abstract

We successfully extended the understandings of the fundamental characteristics of contraction- and stretch-inducible exercising factor (CXC chemokine) production and their potential roles in skeletal muscle cells.

Research Products

• [Journal Article] (2009)
  • Author(s): Nedachi T, Hatakeyama H, Kono T, Sato M, Kanzaki M
  • Journal Title: Am J Physiol Endocrinol Metab 297(4)
• [Journal Article] (2009)
  • Author(s): Suzuki M, Lee HC, Kayasuga Y, Chiba S, Nedachi T, Matsuwaki T, Yamanouchi K, Nishihara M
  • Journal Title: J Reprod Dev 55(4) Pages: 351-355
• [Journal Article] (2009)
  • Author(s): 根建拓、河合隆徳、西原真杉
  • Journal Title: 実験医学 27(9) Pages: 1345-1349
• [Journal Article] Characterization of contraction-inducible CXC chemokines and their roles in C2C12 myocytes (2009)
  • Author(s): 根建拓
  • Journal Title: Am J Physiol Endocrinol Metab 297(4)
  • Peer Reviewed
• [Journal Article] Roles of progranulin in sexual differentiation of the developing brain and adult neurogenesis (2009)
  • Author(s): Suzuki M
  • Journal Title: J Reprod Dev 55(4) Pages: 351-355
• [Journal Article] 成長因子プログラニュリンの機能と神経変性 (2009)
  • Author(s): 根建拓
  • Journal Title: 実験医学 27(9) Pages: 1345-1349
• [Journal Article] (2008)
  • Author(s): Nedachi T, Fujita H, Kanzaki M
  • Journal Title: Am J Physiol Endocrinol Metab 295(5)
• [Journal Article] (2008)
  • Author(s): Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F, Takahashi S
  • Journal Title: Endocrinology 149(7) Pages: 3729-42
• [Journal Article] Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle (2008)
  • Author(s): Nedachi T
  • Journal Title: Am J Physiol Endocrinol Metab 295(5)
  • Peer Reviewed
• [Journal Article] Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin Dl and p27Kipl in FRTL-5 cells (2008)
  • Author(s): Fukushima T
  • Journal Title: Endocrinology 149(7) Pages: 3729-42
  • Peer Reviewed
• [Presentation] (2008)
  • Author(s): Nedachi T, et. al.
  • Organizer: 68th American Diabetes Association Scientific Sessions
  • Place of Presentation: San Francisco, USA
• [Presentation] Identification of contraction-inducible myokines and their impact on insulin responsive GLUT4 translocation in C2C12 myotubes (2008)
  • Author(s): Nedachi T
  • Organizer: 68^<th> American Diabetes Association Scientific Sessions
  • Place of Presentation: San Francisco, USA