| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
The phenotypes of Aquaporin-11 knockout mice were analyzed by histological methods. Cysts formation was observed in the kidney, but no apparent changes were observed in the stomach, small intestine, liver and spleen of the knockout mice. About 20% of the genes expressing in the kidney were changed in their expression in the knockout mice. By the profiling of the expression changes, the mechanisms of the formation of cysts in the kidney of Aquaporin-11 knockout mice were revealed.
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