Searching for susceptible genes acting metabolic disorders induced by a high-fat diet
Project/Area Number |
20780093
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Food science
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Research Institution | Nagoya University |
Principal Investigator |
KOBAYASHI Misato Nagoya University, 大学院・生命農学研究科, 助教 (20456586)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 高脂肪食 / 脂質代謝 / 脂肪肝 / コンソミック / マウス / 血中インスリン / QTL / 遺伝解析 / 糖代謝 / 耐糖能 |
Research Abstract |
To identify susceptible genes for diet-induced obesity, dyslipidemia, and impaired glucose metabolism, we used mouse chromosome substitution strains (consomic) which is a powerful animal model for genetic analyses. Consomic mouse showed that gene(s) on chromosome 12 control susceptibility for high-fat diet induced not only fatty liver but also insulin resistance. In addition, we could select one candidate gene for these traits using gene expression analysis in liver.
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Report
(3 results)
Research Products
(9 results)