Suppressive mechanisms of action of polyphenols in cytokine-induced adipocyte dysfunction
| Project/Area Number |
20780094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
UENO Yuki Aichi Gakuin University, 心身科学部, 講師 (20388060)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ポリフェノール / サイトカイン / 脂肪細胞 / 炎症 |
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| Research Abstract |
In this study, we investigated molecular functions of polyphenols on cytokine-induced dysfunction of adipocytes. 3T3-L1 adipocytes were fully differentiated and treated with TNF-α or LPS after treatment of several polyphenols, and IL-6 concentration in the media was measured. TNF-α increased IL-6 secretion in adipocytes, and curcuminoids suppressed IL-6 concentration. Curcuminoids suppressed LPS-induced nitric oxide levels. These results suggest that curcuminoids may have suppressive effects on cytokine-mediated dysfunction of adipocytes. Now, we try to perform microarray experiments, and examine the gene expression profiles.
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Report
(3 results)
Research Products
(15 results)
