Novel functions of angiotensin system and regulation by food-derived peptide

• Project/Area Number: 20780095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Kyoto University
• Principal Investigator: YAMADA Yuko Kyoto University, 大学院・農学研究科, 助教 (70432341)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 食品機能 / アンジオテンシン / 抗鎮痛 / モネヒネ耐性 / 食品 / 生理活性 / アンジオテンシン系 / novokinin

Research Abstract

We newly found that angiotensin system which is a main regulator of blood pressure participate in anti-opioid activity and morphine tolerance suppression in mice. Anti-opioid activity of angiotensin II is mediated by the AT2 receptor followed by prostaglandin E2 and the EP3 receptor. Morphine tolerance suppressive activity of angiotensin II is mediated by both of the AT1 and AT2 receptors. These results are meaningful in the point that suggests the involvement of angiotensin system in other central actions.

Research Products

• [Journal Article] Angiotensin AT2 receptor agonists act as anti-opioids via EP3 receptor in mice. (2009)
  • Author(s): Yamada Y, Ohinata K, Lipkowski AW, Yoshikawa M.
  • Journal Title: Peptides 30 Pages: 735-739
  • Peer Reviewed
• [Journal Article] AT2受容体アゴニストの抗オピオイド効果とPGE2-EP3受容体 (2009)
  • Author(s): 山田優子、大日向耕作、吉川正明
  • Journal Title: 生体の科学 60 Pages: 468-489
• [Journal Article] Angiotensin AT_2 receptor agonists act as anti-opioids via EP3 receptor in mice.. (2009)
  • Author(s): 山田優子
  • Journal Title: Peptides 30 Pages: 735-739
  • Peer Reviewed
• [Journal Article] AT_2受容体アゴニストの抗オピオイド効果とPGE_2-EP_3受容体 (2009)
  • Author(s): 山田優子
  • Journal Title: 生体の化学 60 Pages: 468-469
• [Journal Article] Angiotensin AT2 receptor agonists act as anti-opioids via EP3 receptor in mice (2009)
  • Author(s): Yamada Y, Ohinata K, Lipkowski AW, Yoshikawa M
  • Journal Title: Peptides 30 Pages: 735-739
  • Peer Reviewed
• [Journal Article] AT2受容体を介して作用する新しい血圧降下ペプチドnovokininとその作用機構 (2008)
  • Author(s): 山田優子、大日向耕作、吉川正明
  • Journal Title: 分子心血管病 9 Pages: 77-82
• [Journal Article] 新しい血圧降下ペプチドnovokininの設計、作用機構および遺伝子改変大豆における生産 (2008)
  • Author(s): 山田優子、大日向耕作、吉川正明
  • Journal Title: 食品加工技術 28 Pages: 1-7
  • NAID: 40016490398
• [Presentation] Angiotensin IIの動脈収縮および弛緩作用はprostaglandin E2およびI2を介している (2010)
  • Author(s): 山田優子、山内大器、臼井八郎、大日向耕作、吉川正明
  • Organizer: 農芸化学会20010度大会
  • Place of Presentation: 東京大学
  • Year and Date: 2010-03-29
• [Presentation] Angiotensin IIの動脈収縮および弛緩作用はprostaglandin E_2およびI_2を介している (2010)
  • Author(s): 山田優子、山内大器、臼井八郎、大日向耕作、吉川正明
  • Organizer: 農芸化学会2010年度大会
  • Place of Presentation: 東京大学
  • Year and Date: 2010-03-29
• [Presentation] Vaso-constricting and relaxing activities of angiotensin II are mediated by prostagladin E2 and I2. (2009)
  • Author(s): 山田優子、山内大器、臼井八郎、大日向耕作、吉川正明
  • Organizer: ペプチド討論会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2009-11-05
• [Presentation] ナタネタンパク質由来ペプチドRIYの抗鎮痛作用とその作用機構 (2009)
  • Author(s): 山田優子、大日向耕作、吉川正明
  • Organizer: 農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
  • Year and Date: 2009-03-28
• [Presentation] a designed hypotensive peptide -mode of action and production in genetically modified crops (2009)
  • Author(s): 山田優子、Novokinin
  • Organizer: 237th American Chemical Society National Meeting & Exposition
  • Place of Presentation: アメリカSalt Lake City
  • Year and Date: 2009-03-25