The establishment of the encompassing screening system for mental functional chemicals and genetics.

• Project/Area Number: 20780097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Kyushu University
• Principal Investigator: OHNUKI Koichiro Kyushu University, 食物栄養学部, 講師 (50378668)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 食品機能 / 精神機能 / 機能性食品 / 動物行動 / 神経新生 / ヤマブシタケ / ペプチド / 生理心理 / VEGF

Research Abstract

This research proposes an establishment of encompassing screening system which brings to discover substances with mental function to support healthy brain function and mental clarity, and to prevent and improve stress-induced mental diseases in modern society. We found that the lower molecular weight peptide from collagen decreased anxiety like behavior and increased neurogenesis in mice. We also found that Hericium erinaceus decreased anxiety in human.

Research Products

• [Journal Article] Enhanced adult neurogenesis and angiogenesis, and altered affective behaveors in mice overexpressing vascular endothelial growth factor 120. (2009)
  • Author(s): Udo H., Yoshida Y., Kino T., Ohnuki K., Mizunoya W., Mukuda T., Sugiyama H.
  • Journal Title: J. Neorosci. 28(53) Pages: 14522-14536
  • Peer Reviewed
• [Journal Article] Enhanced adult neurogenesis and angiogenesis and altered affective beh aviors in mice overexpressing vascular endothelial growth factor 120 (2008)
  • Author(s): Ohnuki K, et.al.
  • Journal Title: Journal of Neuroscience 28(53) Pages: 14522-36
  • Peer Reviewed
• [Journal Article] Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.
  • Author(s): Mayumi N., Kuniyoshi S., Ryuichiro K., Chickako H., Daigo S., Katsuyuki K., Koichiro O.
  • Journal Title: Biomed. Res. (Accepted)
  • Peer Reviewed
• [Presentation] モミ(Abies sibirica)精油が精神負荷作業時の生理的変化に及ぼす効果 (2009)
  • Author(s): 松原恵理・清水邦義・大貫宏一郎・近藤隆一郎
  • Organizer: 第53回TEAC大会
  • Year and Date: 2009-11-08
• [Remarks]
  • URL: http://www.uls-labo.jp/
• [Remarks]
  • URL: http://www.u1s-labojp/index.html
• [Patent(Industrial Property Rights)] 神経細胞分化促進剤 (2009)
  • Inventor(s): 大貫宏一郎, 他6名
  • Industrial Property Rights Holder: UHA味覚糖株式会社
  • Filing Date: 2009-11-30
• [Patent(Industrial Property Rights)] 神経細胞分化促進剤 (2009)
  • Inventor(s): 大貫宏一郎, 他6名
  • Industrial Property Rights Holder: UHA味覚糖株式会社
  • Industrial Property Number: 2009-272229
  • Filing Date: 2009-11-30
• [Patent(Industrial Property Rights)] 抗ストレス剤 (2008)
  • Inventor(s): 大貫宏一郎, 他8名
  • Industrial Property Rights Holder: UHA味覚糖株式会社
  • Filing Date: 2008-10-30
• [Patent(Industrial Property Rights)] 抗ストレス剤 (2008)
  • Inventor(s): 大貫宏一郎, 他8名
  • Industrial Property Rights Holder: UHA味覚糖株式会社
  • Industrial Property Number: 2008-282533
  • Filing Date: 2008-10-31