Screening of peptide inhibiting biofilm formation from glycated protein

Research Project

Project/Area Number	20780098
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Food science
Research Institution	Kyushu University
Principal Investigator	NOMA Seiji 九州大学, 大学院農学研究院, 助教 (40392071)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	食品 / 衛生 / 蛋白質 / 糖 / 細菌 / バイオフィルム / メイラード反応
Outline of Final Research Achievements	Since microorganisms show high resistance to chemical and physical stresses when forming biofilm, inhibition of biofilm formation is important for their effective inactivation. We screened a novel peptide inhibiting biofilm formation of Staphylococcus aureus from α-lactoalbumin glycated by glucose. The peptide without glycation did not show the inhibitory effect. The glycated peptide inhibited the proliferation of S. aureus cells.

Report

(3 results)