Analysis of gastric mucosal defense mechanisms involving gastrointestinal tract-specific calpains
| Project/Area Number |
20780106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
HATA Shoji Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 主任研究員 (10392375)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | カルパイン / 胃粘膜損傷 / カルシウム / 胃粘膜防御 / カルパイン複合体 / タンパク質分解 / 胃粘膜 |
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| Research Abstract |
Calpains are Ca^<2+->dependent cytosolic proteases that are indispensable for various cellular processes. Here we show that mice with mutations in the genes for two gastrointestinal tract-specific calpains 8 and 9 are susceptible to stress-induced gastric injury. Moreover, these calpains form a stable complex, in which both molecules are essential for activity. Gastric mucosal integrity depends on a complex defense system that acts in the face of a variety of irritants, including alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori. The continuous or improper ingestion of these irritants often leads to serious gastropathies. Our results might therefore contribute to the development of new therapeutic strategies for human gastropathies induced by irritants.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Dynamic distribution of muscle-specific calpain adapts to physical stress and its defects cause muscular dystrophy.2010
Author(s)
Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H
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Journal Title
J. Clin. Invest (in press)
Related Report
Peer Reviewed
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[Journal Article] Muscle RING-Finger protein MuRF1 as a connector of muscle energy metabolism and protein synthesis.2008
Author(s)
Koyama S, Hata S(equally contributed first author), Witt C, Ono Y, Lerche S, Ojima K, Chiba T, Doi N, Kitamura F, Tanaka K, Abe K, Witt S, Rybin V, Gasch A, Franz T, Labeit S, Sorimachi H
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Journal Title
J. Mol. Biol 376
Pages: 1224-1236
Related Report
Peer Reviewed
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