Searching for novel nutritional function of fish oil on infants using microarray database.
| Project/Area Number |
20780151
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KIMURA Fumiko Tohoku University, 大学院・農学研究科, 助教 (50321980)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 魚油 / ω-3系脂肪酸 / ラット / 小児栄養 / マイクロアレイ |
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| Research Abstract |
This research aimed to elucidate the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on infant growth using animal experiment and meta-analysis of microarray data. Rats infant brain DHA level declined, when their mothers fed n-3 fatty acid deficient diet at only the gestation and lactation period, although the rate of decline of it was less than other tissues. Kidney n-6 docosapentaenoic acid level was increased in rat infant with n-3 fatty acids insufficient status. Therefore, kidney would be important target tissue for the study of long-chain fatty acid biological function. Alpha-linolenic acid was proved to be unable to improve insufficient n-3 fatty acids status in infant. Therefore, infants need DHA which is abundant in fish oil. About the investigation of meta-analysis of microarray data, the available data related to n-3 fatty acid nutrition were incompatible for meta-analysis at the present point. As listed data is expected to increase, further research would be needed.
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Report
(4 results)
Research Products
(14 results)
