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Searching for novel nutritional function of fish oil on infants using microarray database.

Research Project

Project/Area Number 20780151
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionTohoku University

Principal Investigator

KIMURA Fumiko  Tohoku University, 大学院・農学研究科, 助教 (50321980)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords魚油 / ω-3系脂肪酸 / ラット / 小児栄養 / マイクロアレイ
Research Abstract

This research aimed to elucidate the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on infant growth using animal experiment and meta-analysis of microarray data. Rats infant brain DHA level declined, when their mothers fed n-3 fatty acid deficient diet at only the gestation and lactation period, although the rate of decline of it was less than other tissues. Kidney n-6 docosapentaenoic acid level was increased in rat infant with n-3 fatty acids insufficient status. Therefore, kidney would be important target tissue for the study of long-chain fatty acid biological function. Alpha-linolenic acid was proved to be unable to improve insufficient n-3 fatty acids status in infant. Therefore, infants need DHA which is abundant in fish oil. About the investigation of meta-analysis of microarray data, the available data related to n-3 fatty acid nutrition were incompatible for meta-analysis at the present point. As listed data is expected to increase, further research would be needed.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Long-term supplementation of docosahexaenoic acid-rich, eicosapentaenoic acid-free microalgal oil in n-3 fatty acid-deficient rat pups.2008

    • Author(s)
      F.Kimura, S.Ito, Y.Endo, N.Doisaki, T.Koriyama, T.Miyazawa, K.Fujimoto
    • Journal Title

      Biosci.Biotechnol. Biochem. 72

      Pages: 608-610

    • NAID

      10027524904

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 妊娠・授乳期におけるα-リノレン酸供給の重要性について2010

    • Author(s)
      木村ふみ子、フゲジレト、仲川清隆、宮澤陽夫
    • Organizer
      日本農芸化学会 東北支部・北海道支部合同支部大会(東北支部第145回大会)
    • Place of Presentation
      仙台市
    • Year and Date
      2010-09-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠・授乳期におけるα-リノレン酸供給の重要性について2010

    • Author(s)
      木村ふみ子、フゲジレト、仲川清隆、宮澤陽夫
    • Organizer
      日本農芸化学会東北支部・北海道支部合同支部大会(東北支部第145回大会)
    • Place of Presentation
      仙台市
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠・授乳期のn-3系脂肪酸の制限が仔ラットのリノレン酸代謝に与える影響2010

    • Author(s)
      木村ふみ子, 呼格吉〓〓, 仲川清隆, 宮澤陽夫
    • Organizer
      第62回日本ビタミン学会大会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 離乳期のn-3系脂肪酸不足ラットにおけるαリノレン酸の代謝2010

    • Author(s)
      木村ふみ子、平形一馬、呼格吉楽図、宮澤陽夫
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 胎児・授乳期にn3脂肪酸が不足した新生児ラットの長鎖多価不飽和脂肪酸の分布2010

    • Author(s)
      木村ふみ子、呼格吉楽図、宮澤陽夫
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Excess docosahexaenoic acid gets retroconverted to eicosapentaenoic acid in rat pups of dams fed a diet low in n-3 polyunsaturated fatty acids2009

    • Author(s)
      Fumiko Kimura, Yasushi Endo, Teruo Miyazawa, Kenshiro Fujimoto
    • Organizer
      The 1st International Conference on Lipid Hydroperoxide Biology and Medicine Sendai 2009
    • Place of Presentation
      Hotel Sendai Plaza (Sendai)
    • Year and Date
      2009-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of fat content in the daily diet on the postprandial serum triglyceride levels in rats2009

    • Author(s)
      Fumiko Kimura, Risa Okada, Junko Natsusaka, Teruo Miyazawa, Yasushi Endo, Kenshiro Fujimoto
    • Organizer
      The 1st International Conference on Lipid Hydroperoxide Biology and Medicine Sendai 2009
    • Place of Presentation
      Hotel Sendai Plaza (Sendai)
    • Year and Date
      2009-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of fat content in the daily diet on the postprandial serum triglyceride levels in rats2009

    • Author(s)
      Fumiko Kimura, Risa Okada, Junko Natsusaka, Teruo Miyazawa, Yasushi Endo, Kenshiro Fujimoto
    • Organizer
      The 1st International Conference on Lipid Hydroperoxide Biology and Medicine Sendai 2009
    • Place of Presentation
      Hotel Sendai Plaza(Sendai)
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Excess docosahexaenoic acid gets retroconverted to eicosapentaenoic acid in rat pups of dams fed a diet low in n-3 polyunsaturated fatty acids2009

    • Author(s)
      Fumiko Kimura, Yasushi Endo, Teruo Miyazawa, Kenshiro Fujimoto
    • Organizer
      The 1st International Conference on Lipid Hydroperoxide Biology and Medicine Sendai 2009
    • Place of Presentation
      Hotel Sendai Plaza(Sendai)
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 仔ラットの胃内容物に含まれる長鎖多価不飽和脂肪酸に関する研究2009

    • Author(s)
      木村ふみ子、フゲジレト、仲川清隆、宮澤陽夫
    • Organizer
      日本脂質栄養学会第18 回大会
    • Place of Presentation
      コクヨホール(東京都)
    • Year and Date
      2009-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 仔ラットの胃内容物に含まれる長鎖多価不飽和脂肪酸に関する研究2009

    • Author(s)
      木村ふみ子、フゲジレト、仲川清隆、宮澤陽夫
    • Organizer
      日本脂質栄養学会第18回大会
    • Place of Presentation
      コクヨホール(東京都)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] マヨネーズ投与後のラットの血中脂質濃度の変化に関する研究2008

    • Author(s)
      木村ふみ子、小林禎子、仲川清隆、宮澤陽夫
    • Organizer
      第62回日本栄養・食糧学会大会
    • Place of Presentation
      坂戸市
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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