Insulin signaling and lipid metabolism in fish
Project/Area Number |
20780153
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Fisheries chemistry
|
Research Institution | The University of Tokyo |
Principal Investigator |
KANEKO Gen The University of Tokyo, 大学院・農学生命科学研究科, 助教 (30466809)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 代謝・酵素 / インスリン / 脂肪蓄積 / 代謝 / トラフグ / マダイ / PPARγ / LPL / Foxol / 成長ホルモン受容体 / 脂質蓄積 / 成長ホルモン / インスリン様成長因子 / PPAR / リポタンパク質リパーゼ |
Research Abstract |
We cloned several genes possibly involved in lipid metabolism from torafugu and red seabream, and showed that their transcripts were predominant in tissues containing high quantities of lipid. Changes in expression of these genes suggested that lipid is transported mainly from liver to muscle in torafugu under starved conditions, whereas from adipose tissues to muscle in red seabream. cDNAs encoding hormones and their downstream signaling molecules related to lipid metabolism were also cloned and analyzed for their expression and tissue distribution.
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Report
(3 results)
Research Products
(19 results)