| Project/Area Number |
20780199
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied animal science
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| Research Institution | Kobe University |
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Principal Investigator |
SASAZAKI Shinji Kobe University, 大学院・農学研究科, 助教 (50457115)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウシ / 牛肉 / 不飽和脂肪酸 / 遺伝子 / 脂肪酸組成 |
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| Research Abstract |
Fatty acid composition has become an important trait in the beef industry in terms of beef flavor and decreasing the circulating concentration of LDL cholesterol. In this study, we examined the association between polymorphisms of seven genes (FABP4、LXRα、Cyt b5、ACSL1、ACSL4、DGAT 2 and ACACA) and fatty acid composition.Sequence comparisons revealed 14 single nucleotide polymorphisms in seven genes. Four of them, I74V and V110M in FABP4 and G51E and V133I in LXRα, were nonsynonymous substitutions. The genotypes of FABP4 I74V was significantly associated with palmitoleic acids (C16:1, P=0.0086) content in intramuscular fat. Especially, FABP4 I74V had highly significant effect (P<0.01) on C16:1 proportion, indicating that the I/I homozygote exhibited 0.5% higher percentage than V/V homozygote.
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