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Gonadal function control mechanism in the pituitary gland through long-chain fatty acids as signal molecules.

Research Project

Project/Area Number 20780202
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied animal science
Research InstitutionKinki University

Principal Investigator

MORIYAMA Ryutaro  Kinki University, 理工学部, 講師 (30411573)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords下垂体 / 性腺刺激ホルモン産生細胞 / 脂肪酸 / 低栄養 / 性腺機能 / GPR120 / GnRH / 生殖 / 性腺機能制御 / 脂質 / LH
Research Abstract

Present study showed that long-chain fatty acids such as palmitate may directly activate long-chain fatty acid receptor, GPR120, and down-regulate the synthesis of gonadotropin-releasing hormone receptors on gonadotrophs of the mouse pituitary gland as signal molecules. Moreover, it became clear that GPR120 expression levels were controlled by estrogen on the pituitary gland.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (23 results) Remarks (1 results)

  • [Journal Article] Analytical study of interaction between spdider toxin and glutamate receptors.2010

    • Author(s)
      T.Nishimaru, R.Moriyama, T.Wada, S.Yoshida, K.Shimamoto, M.Nishizawa, S.Ito, Y.Yamaguchi, T.Wakamiya
    • Journal Title

      Peptide Science 2009 :(K.Okamoto(Eds.))

      Pages: 349-352

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analytical study of interaction between spdider toxin and glutamate receptors.2010

    • Author(s)
      T.Nishimaru
    • Journal Title

      Peptide Science 2009

      Pages: 349-352

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational modifications of tubulin in the nervous system2009

    • Author(s)
      N.Fukushima, D.Furuta, Y.Hidaka, R.Moriyama, T.Tsujiuchi
    • Journal Title

      Journal of Neurochemistry Vol.109, Issue 3

      Pages: 683-693

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biochemicalre-evaluation of GFP-tubulin expressed in mammalian cells.2009

    • Author(s)
      D.Furuta, R.Moriyama, N.Fukushima
    • Journal Title

      Science and Technology Vol.21

      Pages: 19-23

    • Related Report
      2010 Final Research Report
  • [Journal Article] Study directed toward the analysis of interaction between the spider toxin NPTX-594 and glutamate receptors.2009

    • Author(s)
      T.Nishimaru, R.Moriyama, T.Wada, S.Yoshida, K.Shimamoto, M.Nishizawa, S.Ito, Y.Yamaguchi, T.Wakamiya
    • Journal Title

      Peptide Science 2008 :(M.Nomizu (Eds.))

      Pages: 401-404

    • NAID

      10027166594

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational modifications of tubulin in the nervous system2009

    • Author(s)
      N.Fukushima
    • Journal Title

      Journal of Neurochemistory 109-3

      Pages: 683-693

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical re-evaluation of GFP-tubulin expressed in mammalian cells2009

    • Author(s)
      D.Furuta
    • Journal Title

      Science and Technology 21

      Pages: 19-23

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Study directed toward the analysis of interaction between the spider toxin NPTX-594 and glutamate receptors2009

    • Author(s)
      T.Nishimaru
    • Journal Title

      Peptide Science 2008

      Pages: 401-404

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational modifications of tubulin in the nervous system2009

    • Author(s)
      N. Fukushima
    • Journal Title

      Journal of Neurochemistry 109

      Pages: 683-693

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation.2008

    • Author(s)
      S.Shano, K.Hatanaka, S.Ninose, R.Moriyama, T.Tsujiuchi, N.Fukushima
    • Journal Title

      Biochimica et Biophysica Acta-Molecular Cell Research Vol.1783, Issue 5

      Pages: 748-759

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1).2008

    • Author(s)
      S.Shano, R.Moriyama, J.Chun, N.Fukushima
    • Journal Title

      Neurochemistry International Vol.52, Issue 1-2

      Pages: 216-220

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A lysophosphatidic acid receptor lacking the PDZ-binding domain is constitutively active and stimulates cell proliferation2008

    • Author(s)
      S. Shano
    • Journal Title

      Biochimica et Biophysica Acta- Molecular Cell Research 1783(5)

      Pages: 748-759

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid stimulates astrocyte proliferation through LPA(1)2008

    • Author(s)
      S. Shano
    • Journal Title

      Neurochemistry International 52(1-2)

      Pages: 216-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical re-evaluation of GFP-tubulin expressed in mammalian cells2008

    • Author(s)
      D. Furuta
    • Journal Title

      Bulletin of Science and Technology 21

      Pages: 19-23

    • Related Report
      2008 Annual Research Report
  • [Presentation] 絶食時のキンギョ脳下垂体におけるGPR120 mRNA発現量について2010

    • Author(s)
      森山隆太郎
    • Organizer
      第103回日本繁殖生物学会大会
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 長鎖脂肪酸はマウス下垂体のGpr120 mRNA発現量を増加させる2010

    • Author(s)
      森山隆太郎
    • Organizer
      第25回下垂体研究会学術集会
    • Place of Presentation
      伊良湖ガーデンホテル
    • Year and Date
      2010-08-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long-chain fatty acids regulate GnRH receptor mRNA expression level in the gonadotrope of the mouse anterior pituitary gland.2010

    • Author(s)
      R.Moriyama
    • Organizer
      43rd Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Midwest Airlines Center, Milwaukee
    • Year and Date
      2010-08-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long-chain fatty acids regulate GnRH receptor mRNA expression level in the gonadotrope of the mouse anterior pituitary gland.2010

    • Author(s)
      R.Moriyama, C.Deura, N.Fukusima
    • Organizer
      43rd Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Midwest Airlines Center, Milwaukee, Wisconsin, U.S.A.
    • Year and Date
      2010-07-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 2-deoxy-D-glucose (2DG) induced glucoprivation suppressed gonadotropin-releasing hormone receptor (GnRH-R) and follicular stimulating hormone β subunit (FSHβ) mRNA expression levels in the LβT2 gonadotroph cells.2010

    • Author(s)
      R.Moriyama, A.Nakai, N.Fukushima
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 2-deoxy-D-glucose(2DG)induced glucoprivation suppressed go nadotropin-releasing hormone receptor(GnRH-R)and follicular stimulating hormone β subunit(FSHβ)mRNA expression levels in the LβT2 gonadotroph cells2010

    • Author(s)
      森山隆太郎
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto International Conference Hall
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Palmitate regulates GnRH receptor mRNA expression level in the gonadotrope of the mouse anterior pituitary gland2010

    • Author(s)
      出浦慎哉
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto International Conference Hall
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] クモ毒及びグルタミン酸受容体間の相互作用の分析研究2009

    • Author(s)
      西丸貴弘
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Lysophosphatidic acid receptor 3 is involved in neurite branching formation in cultured hippocampal neurons2009

    • Author(s)
      D.Furuta
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高脂肪食負荷がゴナドトロフの長鎖脂肪酸受容体Gpr120と性腺刺激ホルモンmRNA発現に与える影響2009

    • Author(s)
      出浦慎哉、福嶋伸之、森山隆太郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      奈良、近畿大学
    • Year and Date
      2009-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] グルコースの利用阻害は下垂体の性腺刺激ホルモン産生細胞でGnRHレセプターおよびFSHβmRNA発現量を抑制する2009

    • Author(s)
      森山隆太郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高脂肪食負荷がゴナドトロフの長鎖脂肪酸受容体Gpr120と性腺刺激ホルモンmRNA発現に与える影響2009

    • Author(s)
      出浦慎哉
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] グルコースの利用阻害はゴナドトロフ株化細胞LβT2で性腺刺激ホルモン放出ホルモン受容体(GnRH-R)と卵胞刺激ホルモンβ鎖(FSHβ)mRNA発現量を抑制する2009

    • Author(s)
      森山隆太郎
    • Organizer
      第24回下垂体研究会学術集会
    • Place of Presentation
      小牧温泉青森屋
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高脂肪食負荷がゴナドトロフの長鎖脂肪酸受容体Gpr120と性腺刺激ホルモンmRNA発現に与える影響2009

    • Author(s)
      出浦慎哉
    • Organizer
      第24回下垂体研究会学術集会
    • Place of Presentation
      小牧温泉青森屋
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] LPA induces neurite shape changes through LPA32009

    • Author(s)
      D.Furuta
    • Organizer
      4^<th> International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      National Center of Sciences
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] LPA1mRNA expression level in mouse pituitary gonadotropes is enhanced by ovariectomy2009

    • Author(s)
      森山隆太郎
    • Organizer
      4^<th> International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      National Center of Sciences
    • Year and Date
      2009-05-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Palmitate regulates GnRH receptor mRNA expression level in the gonadotrope of the mouse pituitary gland2009

    • Author(s)
      出浦慎哉
    • Organizer
      4^<th> International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      National Center of Sciences
    • Year and Date
      2009-05-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Palmitate regulates GnRH receptor mRNA expression level in the gonadotrope of the mouse pituitary gland.2009

    • Author(s)
      R.Moriyama, C.Deura, N.Fukushima
    • Organizer
      第5回武田科学振興財団薬科学シンポジウム
    • Place of Presentation
      東京、グランドプリンスホテル高輪
    • Year and Date
      2009-05-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Palmitate regulates GnRH receptor mRNA expression in the gonadotrope of the mouse anterior pituitary2009

    • Author(s)
      森山隆太郎
    • Organizer
      第5回武田科学振興財団薬科学シンポジウム
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Long-chain fatty acids regulate GnRH receptor mRNA expression in the gonadotrope of the mouse anterior pituitary gland2008

    • Author(s)
      R. Moriyama
    • Organizer
      The Society for Neuroscience
    • Place of Presentation
      Washington Convention Center
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] パルミチン酸はゴナドトロフのGnRHレセプターmRNA発現量を制御する2008

    • Author(s)
      出浦慎哉
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      九州大学
    • Year and Date
      2008-09-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長鎖脂肪酸はゴナドトロフのGnRHレセプターmRNA発現量を制御する2008

    • Author(s)
      出浦慎哉
    • Organizer
      下垂体研究会
    • Place of Presentation
      政策研究大学院大学
    • Year and Date
      2008-08-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Palmitate regulates GnRH receptor mRNA expression in the gonadotrope of the mouse anterior pituitary.2008

    • Author(s)
      R. Moriyama
    • Organizer
      日本神経科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.life.kindai.ac.jp/~mory/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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