| Project/Area Number |
20780204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
YOSHIMURA Aya Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 研究員 (90466483)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 寄生虫 / フィラリア / ヤブカ / 行動 / イヌフィラリア / 侵入行動 / 宿主 / 媒介者 / 病原体伝播 |
|---|
| Research Abstract |
The mosquito-borne disease cycle is maintained by blood-feeding and comprises an interaction between the pathogens and the blood-feeding behavior. We will understand of the interaction by analyzing entry mechanism of infective larvae from mosquito mouthparts to host skin in filariasis. In order to identify the attractants on blood-feeding, we investigated the response of Dirofilaria immitis infective larvae L3 to holes like a puncture wound made on agar plates. As a result, L3 showed the behavior to go into holes without blood. The observations suggest that the skin-penetrating of D. immitis larvae have at least two behavioral process, which are host recognition and host penetration. Furthermore, RNAi-based knockdown of development-related genes in L3 stage suggested that development mechanism of filaria is closely related with internal environments of host animals.
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