| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Erythropoietin (EPO) is a crucial hematopoietic cytokine, and it is suggested that endogenous EPO has a neuroprotective function from hypoxic damage. In this study, the expression of EPO-mRMA was observed in hypothalamo-hypophyseal system under the hypoxic condition, as well as other parts of the central nervous system. The time-dependent expression of EPO-mRNA was divided into two patterns ; hypoxia-responsive or constant. Both patterns shown in the hypothalamo-hypophyseal system imply the region-specific control of EPO gene expression.
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