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The role of erythropoietin in the hypothalamo-hypophyseal system

Research Project

Project/Area Number 20780205
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionIwate University

Principal Investigator

YAMADA Misuzu  Iwate University, 農学部, 准教授 (10414012)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsエリスロポイエチン / 脳・神経 / 低酸素 / エリスロポエチン / ラット
Research Abstract

Erythropoietin (EPO) is a crucial hematopoietic cytokine, and it is suggested that endogenous EPO has a neuroprotective function from hypoxic damage. In this study, the expression of EPO-mRMA was observed in hypothalamo-hypophyseal system under the hypoxic condition, as well as other parts of the central nervous system. The time-dependent expression of EPO-mRNA was divided into two patterns ; hypoxia-responsive or constant. Both patterns shown in the hypothalamo-hypophyseal system imply the region-specific control of EPO gene expression.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2011 2009 2008

All Presentation (8 results)

  • [Presentation] 摂水量変動がラット神経性下垂体でのエリスロポイエチン遺伝子発現に与える影響2011

    • Author(s)
      山田美鈴、山本欣郎
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      東京農工大学(東京都)
    • Year and Date
      2011-03-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 摂水量変動がラット神経性下垂体でのエリスロポイエチン遺伝子発現に与える影響2011

    • Author(s)
      山田美鈴、山本欣郎
    • Organizer
      第151回日本獣医学会学術集会
    • Place of Presentation
      東京農工大学
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット中枢神経系における低酸素刺激によるエリスロポイエチン-mRNA発現亢進2009

    • Author(s)
      山田美鈴、若井淳、山本欣郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Year and Date
      2009-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット中枢神経系における低酸素刺激によるエリスロポイエチン-mRNA発現亢進2009

    • Author(s)
      山田美鈴、若井淳、山本欣郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Altered expression of erythropoietin mRNA in the central nervous system of hypoxic rats2009

    • Author(s)
      Misuzu Yamada、Yoshio Yamamoto、Jun Wakai、Kouki Kato
    • Organizer
      36^<th> International congress of physiological sciences
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Altered expression of erythropoietin mRNA in the central nervous system of hypoxic rats2009

    • Author(s)
      Misuzu Yamada, Yoshio Yamamoto, Jun Wakai, Kouki Kato
    • Organizer
      36th International congress of physiological sciences
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素刺激によるラット中枢神経系でのエリスロポイエチン-mRNA発現変化2008

    • Author(s)
      山田美鈴、若井淳、加藤弘毅、山本欣郎
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンションセンター(宮崎県)
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 低酸素刺激によるラット中枢神経系でのエリスロポイエチン-mRNA発現変化2008

    • Author(s)
      山田美鈴、若井淳、加藤弘毅、山本欣郎
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンションセンター・宮崎
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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