The role of erythropoietin in the hypothalamo-hypophyseal system
Project/Area Number |
20780205
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Basic veterinary science/Basic zootechnical science
|
Research Institution | Iwate University |
Principal Investigator |
YAMADA Misuzu Iwate University, 農学部, 准教授 (10414012)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | エリスロポイエチン / 脳・神経 / 低酸素 / エリスロポエチン / ラット |
Research Abstract |
Erythropoietin (EPO) is a crucial hematopoietic cytokine, and it is suggested that endogenous EPO has a neuroprotective function from hypoxic damage. In this study, the expression of EPO-mRMA was observed in hypothalamo-hypophyseal system under the hypoxic condition, as well as other parts of the central nervous system. The time-dependent expression of EPO-mRNA was divided into two patterns ; hypoxia-responsive or constant. Both patterns shown in the hypothalamo-hypophyseal system imply the region-specific control of EPO gene expression.
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Report
(4 results)
Research Products
(8 results)