Studies on the esophageal motility in the gastroesophageal reflux disease-model animals

• Project/Area Number: 20780206
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Gifu University
• Principal Investigator: SHIINA Takahiko Gifu University, 応用生物科学部, 准教授 (90362178)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 食道 / 胃食道逆流症 / 疾患モデル / 神経 / 横紋筋

Research Abstract

To clarify the pathogenesis of Gastroesophageal reflux disease (GERD), the esophageal motility control in the house musk shrew (Suncus murinus), which is a new GERD-model animal. Morphological studies revealed that the inner and outer muscle layers of the shrew esophagus are entirely composed of the striated muscles. Functional examinations indicated that the esophageal motility in the shrew is regulated by both extrinsic (vagal) and intrinsic neurons. Reflux of acids might activate the esophageal neurons and then alter the motor activity. Future research using the shrew will explore issues of GERD further.

Research Products

• [Journal Article] Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats. (2011)
  • Author(s): Iwami, M., Shiina, I., Hirayama, H., Shima, T., Takewaki, T., Shimizu Y.
  • Journal Title: J.Nat.Med. 65 Pages: 89-94
  • NAID: 10029460495
  • Peer Reviewed
• [Journal Article] Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats. (2011)
  • Author(s): Iwami, M., Shiina, T., Hirayama, H., Shima, T., Takewaki, T., Shimizu Y.
  • Journal Title: J.Nat.Med. Volume: 65 Pages: 89-94
  • NAID: 10029460495
  • Peer Reviewed
• [Journal Article] Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. (2010)
  • Author(s): Shiina, T., Shima, T., Hirayama, H., Kuramoto, H., Takewaki, T., Shimizu, Y.
  • Journal Title: Eur.J.Pharmacol. 628 Pages: 202-206
  • Peer Reviewed
• [Journal Article] Contractile properties of esophageal striated muscle : comparison with cardiac and skeletal muscles in rats. (2010)
  • Author(s): Shiina, T., Shima, T., Masuda, K., Hirayama, H., Iwami, M., Takewaki, T., Kuramoto, H., Shimizu, Y.
  • Journal Title: J.Biomed.Biotech. vol.2010
  • Peer Reviewed
• [Journal Article] The neural regulation of the mammalian esophageal motility and its implication for esophageal diseases. (2010)
  • Author(s): Shiina, T., Shima, T., Worl, J., Neuhuber, W.L., Shimizu, Y.
  • Journal Title: Pathophysiology. 17(review) Pages: 129-133
  • Peer Reviewed
• [Journal Article] The neural regulation of the mammalian esophageal motility and its implication for esophageal diseases. (2010)
  • Author(s): Shiina, T., Shima, T., Worl, J., Neuhuber, W.L., Shimizu, Y.
  • Journal Title: Pathophysiology Volume: 17 Pages: 129-133
  • Peer Reviewed
• [Journal Article] Contractile properties of esophageal striated muscle : comparison with cardiac and skeletal muscles in rats. (2010)
  • Author(s): Shiina, T., Shima, T., Masuda, K., Hirayama, H., Iwami, M., Takewaki, T., Kuramoto, H., Shimizu, Y.
  • Journal Title: J.Biomed.Biotech. Volume: 2010 Pages: 459789-459789
  • Peer Reviewed
• [Journal Article] Galanin modulates vagally induced contractions in the mouse esophagus. (2009)
  • Author(s): Boudaka, A., Worl, J., Shiina, T., Shimizu, Y., Takewaki, T., Neuhuber, W.L.
  • Journal Title: Neurogastroenterol.Motil. 21 Pages: 180-188
  • Peer Reviewed
• [Journal Article] Enteric co-innervation of esophageal striated muscle fibers : A phylogenetic study. (2009)
  • Author(s): Hempfling, C., Seibold, R., Shiina, T., Heimler, W., Neuhuber, W.L., Worl, J.
  • Journal Title: Auton.Neurosci. 151 Pages: 135-141
  • Peer Reviewed
• [Journal Article] Enteric co-innervation of esophageal striated muscle fibers : A phylogenetic study. (2009)
  • Author(s): Hempfling, C., Seibold, R., Shiina, T., Heimler, W., Neuhuber, W.L., WorI, J.
  • Journal Title: Auton.Neurosci. 151 Pages: 135-141
  • Peer Reviewed
• [Journal Article] Galanin modulates vagally induced contractions in the mouse oesophagus (2009)
  • Author(s): Boudaka A, Worl J, Shiina T, Shimizu Y, Takewaki T, Neuhuber WL.
  • Journal Title: Neurogastroenterol Motil 21 Pages: 180-188
  • Peer Reviewed
• [Presentation] 局所神経経路によるラット食道横紋筋運動に対する抑制性制御 (2011)
  • Author(s): 椎名貴彦, 嶋剛士, 藏本博史, 志水泰武
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: (学会誌上での開催)
  • Year and Date: 2011-03-29
• [Presentation] 嘔吐する小型実験動物スンクス(Suncus murinus)の食道の特徴 (2011)
  • Author(s): 椎名貴彦
  • Organizer: 日本病態生理学会第2回サテライトセミナー
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2011-01-23
• [Presentation] 嘔吐する小型実験動物スンクス(Suncus murinus)の食道の特徴 (2011)
  • Author(s): 椎名貴彦
  • Organizer: 日本病態生理学会第2回サテライトセミナー
  • Place of Presentation: 神戸
• [Presentation] 局所神経経路によるラット食道横紋筋運動に対する抑制性制御 (2011)
  • Author(s): 椎名貴彦, 嶋剛士, 藏本博史, 志水泰武
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 誌上にて開催
• [Presentation] ハムスター食道横紋筋における神経筋接合部の形態および機能的特徴 (2010)
  • Author(s): 椎名貴彦, Jurgen Worl, Winfried Neuhuber, 嶋剛士, 志水泰武
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 北海道帯広市
  • Year and Date: 2010-09-17
• [Presentation] 新生子ラット食道筋に対する神経支配および収縮制御機構 (2010)
  • Author(s): 椎名貴彦, 中森智昭, 平山晴子, 嶋剛士, 藏本博史, 志水泰武
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 岩手県盛岡市
  • Year and Date: 2010-05-21
• [Presentation] ラット食道横紋筋の収縮特性および内在神経系による運動調節機構 (2010)
  • Author(s): 椎名貴彦, 武脇義, 志水泰武
  • Organizer: 第149回日本獣医学会学術集会
  • Place of Presentation: 東京都武蔵野市
  • Year and Date: 2010-03-26
• [Presentation] スンクス食道の形態学的および薬理学的特徴 (2010)
  • Author(s): 椎名貴彦, 嶋剛士, 藏本博史, 武脇義, 志水泰武
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-03-18
• [Presentation] 嘔吐する小型実験動物スンクスの食道筋構造と神経支配 (2010)
  • Author(s): 椎名貴彦, 平山晴子, 嶋剛士, 志水泰武
  • Organizer: 第20回日本病態生理学会大会
  • Place of Presentation: 奈良県橿原市
  • Year and Date: 2010-01-23
• [Presentation] 嘔吐する小型実験動物スンクスの食道筋構造と神経支配 (2010)
  • Author(s): 椎名貴彦, 平山晴子, 嶋剛士, 志水泰武
  • Organizer: 第20回日本病態生理学会大会
  • Place of Presentation: 奈良
• [Presentation] スンクス食道の形態学的および薬理学的特徴 (2010)
  • Author(s): 椎名貴彦, 嶋剛士, 藏本博史, 武脇義, 志水泰武
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] ラット食道横紋筋の収縮特性および内在神経系による運動調節機構 (2010)
  • Author(s): 椎名貴彦, 武脇義, 志水泰武
  • Organizer: 第149回日本獣医学会学術集会
  • Place of Presentation: 東京
• [Presentation] 新生子ラット食道 筋に対する神経支配および収縮制御機構 (2010)
  • Author(s): 椎名貴彦, 中森智昭, 平山晴子, 嶋剛士, 藏本博史, 志水泰武
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
• [Presentation] ハムスター食道横紋筋における神経筋接合部の形態および機能的特徴 (2010)
  • Author(s): 椎名貴彦,Jurgen Worl,Winfried Neuhuber,嶋剛士,志水泰武
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広
• [Presentation] スンクス(Suncus murinus)食道運動における神経性制御 (2009)
  • Author(s): 椎名貴彦, Jurgen Worl, 平山晴子, 嶋剛士, Winfried Neuhuber, 武脇義, 志水泰武
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取市
  • Year and Date: 2009-09-26
• [Presentation] Neuronal regulation of the esophageal motility in Suncus murinus (a house musk shrew). (2009)
  • Author(s): Shiina, T., Worl, J., Neuhuber, W.L., Shima, T., Takewaki, T., Shimizu, Y.
  • Organizer: 6th Congress of the International Society for Autonomic Neuroscience (ISAN 2009)
  • Place of Presentation: シドニー(オーストラリア)
  • Year and Date: 2009-09-03
• [Presentation] Modulatory actions of tachykinins on the striated and smooth muscle motility in the rat esophagus. (2009)
  • Author(s): Shiina, T., Shima, T., Hirayama, H., Boudaka, A., Worl, J., Neuhuber, W.L., Takewaki, T., Shimizu, Y.
  • Organizer: XXXVI International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: 京都市
  • Year and Date: 2009-07-29
• [Presentation] ラット食道運動におけるカプサイシン感受性神経の役割 (2009)
  • Author(s): 椎名貴彦、嶋剛士、バウダカアッマール、武脇義、志水泰武
  • Organizer: 第19回日本病態生理学会大会
  • Place of Presentation: 所沢市民文化センター(埼玉県)
  • Year and Date: 2009-01-24
• [Presentation] ラット食道運動におけるカプサイシン感受性神経の役割 (2009)
  • Author(s): 椎名貴彦, 嶋剛士, 武脇義, 志水泰武
  • Organizer: 第19回日本病態生理学会大会
  • Place of Presentation: 埼玉
• [Presentation] Modulatory actions of tachykinins on the striated and smooth muscle motility in the rat esophagus. (2009)
  • Author(s): Shiina, T. , Shima, T., Hirayama, H., Boudaka, A., Worl, J., Neuhuber, W.L., Takewaki, T., Shimizu, Y.
  • Organizer: The XXXVI International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
• [Presentation] Neuronal regulation of the esophageal motility in Suncus murinus (a house musk shrew). (2009)
  • Author(s): Shiina, T ., Worl, J., Neuhuber, W.L., Shima, T., Takewaki, T.. Shimizu, Y.
  • Organizer: 6th Congress of the International Society for Autonomic Neuroscience (ISAN 2009)
  • Place of Presentation: Sydney, Australia
• [Presentation] スンクス(Suncus murinus)食道運動における神経性制御 (2009)
  • Author(s): 椎名貴彦, Jurgen Worl, 平山晴子, 嶋剛士, Winfried Neuhuber, 武脇義, 志水泰武
  • Organizer: 第148回日本獣医学会学術集会
  • Place of Presentation: 鳥取
• [Presentation] ラット食道粘膜筋板平滑筋の収縮を制御する神経伝達物質 (2008)
  • Author(s): 椎名貴彦、嶋剛士、武脇義、志水泰武
  • Organizer: 第55回中部日本生理学会
  • Place of Presentation: 愛知医科大学(愛知県)
  • Year and Date: 2008-10-17
• [Presentation] ラット食道粘膜筋板平滑筋の収縮を制御する神経伝達物質 (2008)
  • Author(s): 椎名貴彦, 嶋剛士, バウダカ アッマール, 武脇義, 志水泰武
  • Organizer: 第55回中部日本生理学会大会
  • Place of Presentation: 愛知
• [Remarks] ホームページ等
  • URL: http://wwwl.gifu-u.ac.jp/~yshimizu/physiologv/toppage.html
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~yshimizu/physiology/top_page.html
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~yshimizu/physiology/top_page.html
• [Remarks]
  • URL: http://www1.gifu-u.acjp/~yshimizu/physiology/top_page.html