| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
To clarify the pathogenesis of Gastroesophageal reflux disease (GERD), the esophageal motility control in the house musk shrew (Suncus murinus), which is a new GERD-model animal. Morphological studies revealed that the inner and outer muscle layers of the shrew esophagus are entirely composed of the striated muscles. Functional examinations indicated that the esophageal motility in the shrew is regulated by both extrinsic (vagal) and intrinsic neurons. Reflux of acids might activate the esophageal neurons and then alter the motor activity. Future research using the shrew will explore issues of GERD further.
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