| Project/Area Number |
20780211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
YAMAMOTO Ichiro Nippon Veterinary and Life Science University, 獣医学部, 助教 (00424763)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | モチリン / グレリン / 受容体 / GPCR / ニワトリ / cDNAクローニング / ウシ / Gタンパク共役型受容体 / GPR39 / シグナル伝達 / 生理学 / 生理活性 / 発生・分化 |
|---|
| Research Abstract |
Motilin and ghrelin are peptide hormones involved in gastrointestinal motility. GPR38, initially cloned as an orphan receptor, is now considered a specific receptor for motilin. Previously, molecular characterization of the motilin receptor had only been performed in mammalian and fish species. We cloned cDNA for chicken motilin receptor from the duodenum and characterized its primary structure, tissue distribution, and biological activity. Our data suggest that chicken motilin receptor is largely involved in gastrointestinal functions at pre- and post-hatch periods through an intracellular signaling pathway accompanied by an increase in Ca^<2+> levels.
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