Role of keratinocytes in the development of atopic dermatitis
| Project/Area Number |
20780224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
OHMORI Keitaro Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 助教 (20466915)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アレルギー / 免疫 / 炎症 / 皮膚 / 動物 |
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| Research Abstract |
The importance of keratinocytes in the development of atopic dermatitis was evaluated by using a murine model of atopic dermatitis and dogs. We found that increased cell proliferation of keratinocytes and the local crosstalk between keratinocytes and mast cells in the skin were pivotal in the pathogenesis and clinical signs of atopic dermatitis. We also revealed that improvement of skin barrier function could be effective for alleviating atopic dermatitis and would be a local therapeutic option.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] A novel NF-κB inhibitor improves glucocorticoid 1 sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors2010
Author(s)
Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.
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Journal Title
Research in Veterinary Science (in press)
Related Report
Peer Reviewed
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[Journal Article] A novel NF-κB inhibitor improves glucocorticoid 1 sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors2010
Author(s)
Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.
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Journal Title
Research in Veterinary Science (In press)
Related Report
Peer Reviewed
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