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Role of keratinocytes in the development of atopic dermatitis

Research Project

Project/Area Number 20780224
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Clinical veterinary science
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

OHMORI Keitaro  Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 助教 (20466915)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアレルギー / 免疫 / 炎症 / 皮膚 / 動物
Research Abstract

The importance of keratinocytes in the development of atopic dermatitis was evaluated by using a murine model of atopic dermatitis and dogs. We found that increased cell proliferation of keratinocytes and the local crosstalk between keratinocytes and mast cells in the skin were pivotal in the pathogenesis and clinical signs of atopic dermatitis. We also revealed that improvement of skin barrier function could be effective for alleviating atopic dermatitis and would be a local therapeutic option.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (6 results)

  • [Journal Article] Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus2010

    • Author(s)
      Ohmori K, Tanaka A, Makita Y, Takai M, Yoshinari Y, Matsuda H.
    • Journal Title

      Veterinary Dermatology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel NF-κB inhibitor improves glucocorticoid 1 sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors2010

    • Author(s)
      Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.
    • Journal Title

      Research in Veterinary Science (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cultivation and characterization of canine skin-derived mast cells2010

    • Author(s)
      Kawarai S, Masuda K, Ohmori K, Matsuura S, Yasuda N, Nagata M, Sakaguchi M, Tsujimoto H.
    • Journal Title

      Journal of Veterinary Medical Science 72(2

      Pages: 131-140

    • NAID

      130000134517

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus2010

    • Author(s)
      Ohmori K, Tanaka A, Makita Y, Takai M, Yoshinari Y, Matsuda H.
    • Journal Title

      Veterinary Dermatology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel NF-κB inhibitor improves glucocorticoid 1 sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors2010

    • Author(s)
      Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.
    • Journal Title

      Research in Veterinary Science (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cultivation and characterization of canine skin-derived mast cells2010

    • Author(s)
      Kawarai S, Masuda K, Ohmori K, Matsuura S, Yasuda N, Nagata M, Sakaguchi M, Tsujimoto H.
    • Journal Title

      Journal of Veterinary Medical Science 72(2)

      Pages: 131-140

    • NAID

      130000134517

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen2009

    • Author(s)
      Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H.
    • Journal Title

      The Journal of Immunology 182(5)

      Pages: 2835-41

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral supplementation with Lactobacillus rhamnosus CGMCC 1. 3724 prevents development of atopic dermatitis in NC/NgaTnd mice possibly by modulating local production of IFN-γ2009

    • Author(s)
      Tanaka A, Jung K, Benyacoub J, Prioult G, Okamoto N, Ohmori K, Blum S, Mercenier A, Matsuda H.
    • Journal Title

      Experimental Dermatology 18(12)

      Pages: 1022-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen2009

    • Author(s)
      Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H
    • Journal Title

      The Journal of Immunology 182

      Pages: 2835-41

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral supplementation with Lactobacillus rhamnosus CGMCC 1.3724 prevents development of atopic dermatitis in NC/NgaTnd mice possibly by modulating local production of IFN-γ2009

    • Author(s)
      Tanaka A, Jung K, Benyacoub J, Prioult G, Okamoto N, Ohmori K, Blum S, Mercenier A, Matsuda H
    • Journal Title

      Experimental Dermatology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells2008

    • Author(s)
      Ohmori K, Kawarai S, Yasuda N, Tanaka A, Matsuda H, Nishimura R, Sasaki N, Tsujimoto H, Masuda K.
    • Journal Title

      Veterinary Immunology and Immunopathology 126(1-2)

      Pages: 43-53

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells2008

    • Author(s)
      Ohmori K, Kawarai S, Yasuda N, Tanaka A, Matsuda H, Nishimura R, Sasaki N, Tsuiimoto H, Masuda K
    • Journal Title

      Veterinary Immunology and Immunopathology 126

      Pages: 43-53

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 皮膚炎自然発症犬を用いた高純度軟化水による皮膚炎改善効果の検証2009

    • Author(s)
      大森啓太郎、田中あかね、巻田優花、高井政貴、吉成佑治、松田浩珍
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田キャッスルホテル(秋田県)
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] イヌの痒みに対する高純度軟化水を用いたシャンプー療法の臨床的効果2009

    • Author(s)
      大森啓太郎、田中あかね、巻田優花、高井政貴、吉成佑治、松田浩珍
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      とりぎん文化会館(鳥取県)
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 高純度軟化水(UPSW)のアトピー性皮膚炎改善効果4. 皮膚バリア損傷モデルでの検証2008

    • Author(s)
      田中あかね、大森啓太郎、高井政貴、吉成佑治、松田浩珍
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都千代田区東京国際フォーラム
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトおよびイヌの皮膚バリア機能に及ぼす高純度軟化水の影響2008

    • Author(s)
      大森啓太郎、田中あかね、高井正貴、吉成佑治、松田浩珍
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      宮崎県宮崎市ワールドコンベンションセンター
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高純度軟化水(UPSW)のアトピー性皮膚炎改善効果4. 皮膚バリア損傷モデルでの検証2008

    • Author(s)
      田中あかね、大森啓太郎、高井政貴、吉成佑治、松田浩珍
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒトおよびイヌの皮膚バリア機能に及ぼす高純度軟化水の影響2008

    • Author(s)
      大森啓太郎、田中あかね、高井正貴、吉成佑治、松田浩珍
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンションセンター(宮崎県)
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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