Analysis of the fibrogenic mechanism mediated by MMP activity: basic study to an anti-fibrotic therapy.

• Project/Area Number: 20780227
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Clinical veterinary science
• Research Institution: Kitasato University
• Principal Investigator: HORI Yasutomo Kitasato University, 獣医学部・小動物第2内科学研究室, 講師 (20406896)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 内科 / 治療 / 獣医学 / 循環器・高血圧

Research Abstract

内科
治療

Research Products

• [Journal Article] Doxycycline attenuates isoproterenolinduced myocardial fibrosis and matrix metalloproteinase activity in rats. (2009)
  • Author(s): 堀泰智, 国広章一, 佐藤真伍(9名、1番目)
  • Journal Title: Biol Pharm Bull. 32 Pages: 1678-1682
  • NAID: 130000116926
  • Peer Reviewed
• [Journal Article] Doxycycline attenuates isoproterenol-induced myocardial fibrosis and matrix metalloproteinase activity in rats. (2009)
  • Author(s): Hori Y, Kunihiro S, Sato S, Yoshioka K, Hara Y, Kanai K, Hoshi F, Itoh N, Higuchi S.
  • Journal Title: Biol Pharm Bull. 32 Pages: 1678-1682
  • NAID: 130000116926
  • Peer Reviewed
• [Presentation] ラット心筋線維芽細胞におけるMMPの働き (2009)
  • Author(s): 佐野直哉, 堀泰智(8名、2番目)
  • Organizer: 北里大学ハイテクリサーチセンター研究中間報告会
  • Place of Presentation: 北里大学(青森)
  • Year and Date: 2009-07-25
• [Presentation] ラット心筋線維芽細胞におけるMMPの働き (2009)
  • Author(s): 佐野直哉
  • Organizer: 北里大学ハイテクリサーチセンター研究中間報告会
  • Place of Presentation: 北里大学(青森県)
  • Year and Date: 2009-07-25
• [Presentation] アルドステロン受容体阻害を介したMMP発現・活性と心筋線維化の関係 (2008)
  • Author(s): 中村和弘
  • Organizer: 第88回日本獣医循環器学会
  • Place of Presentation: 大宮
  • Year and Date: 2008-06-28