Analysis for regulation of transcription factor FOXO1 by post-translational modification and mechanism of determination of lifspan
| Project/Area Number |
20780237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
DAITOKU Hiroaki University of Tsukuba, 大学院・生命環境科学研究科, 講師 (30361314)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 転写制御 / 翻訳後修飾 / 寿命 / 酸化ストレス / FOXO1 / 線虫 / アポトーシス |
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| Research Abstract |
In response to oxidative stress, the Forkhead transcription factor FOXO1 is activated and thereby promotes the expression of anti-oxidant genes. Moreover, FOXO has been shown to act as lifespan modulator in model organisms. Here we have demonstrated that post-translational modification plays an important role in regulation of FOXO1 function. Furthermore, by using genetic experiments in C. elegans, we have revealed that arginine methylation of FOXO1 is involved in the regulation of lifespan.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt2008
Author(s)
Yamagata, K., Daitoku, H., Takahashi, Y., Namiki, K., Hisatake, K., Kako, K., Mukai, H., Kasuya, Y., Fukamizu, A.
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Journal Title
Mol. Cell 32
Pages: 221-231
Related Report
Peer Reviewed
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