Structure of reactive aggregate of lithium reagents and its application to the generation of highly-activated reagents.
| Project/Area Number |
20790007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAMOTO Yasutomo Kyoto University, 薬学部, 助教 (10452278)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 有機リチウム / NMR / 構造解析 / 多成分錯体 / 不斉反応 |
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| Research Abstract |
Organolithiums are one of the most frequently-used reagents in synthetic chemistry. To better understand their reactivity and reaction mechanisms, it is necessary to elucidate the structure of reactive organolithium reagents. We found that a ternary complex reagent of lithium ester enolate-chiral diether-lithium diisopropylamide was formed in an equimolar mixture of these reagents in toluene based on low-temperature NMR spectroscopy. This complex shows high reactivity and enantioselectivity in an asymmetric Michael reaction.
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Report
(4 results)
Research Products
(31 results)
