| Project/Area Number |
20790012
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHIGENAGA Akira The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (10423394)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ペプチド / 有機合成化学 / 刺激応答 / ペプチド結合切断 / ケージド化合物 / シャトルペプチド |
|---|
| Research Abstract |
Accumulation of a disease related mutated protein in a nucleus is observed in some intractable diseases. To treat these diseases, elimination of the mutated protein from nucleus is thought to be applicable. Therefore, we decided to develop a nucleocytoplasmic shuttle peptide, which beats inside a nucleus before exposure to a stimulus but it returns to a cytoplasm after exposure to a stimulus, with potential applicability to eliminate the mutated protein from a nucleus. As a results, we sucsessfully developed several stimulus-responsive amino acids which can be used for controlling a peptidyl function by a stimulus, and asymmetric synthesis of a key synthetic intermediate of the stimulus-responsive amino acids was achieved.
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