Development of the nucleoside analogs to harmonize with in vivo molecular function
Project/Area Number |
20790013
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Chemical pharmacy
|
Research Institution | Kyushu University |
Principal Investigator |
TANIGUCHI Yosuke Kyushu University, 大学院・薬学研究院, 助教 (00452714)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 3本鎖DNA / W字型人工核酸 / アンチジーン / ミスマッチサイト / 機能性人工核酸 / 分子認識 / 機能融合 / W-字型人工核酸 |
Research Abstract |
In this study, we designed and synthesized the nucleoside analogs which interact with duplex DNA. Moreover, we aimed to establish the basic technology of the regulation of the gene expression using these nucleoside analogs. We have found that oligonucleotide containing the nucleoside analogs formed the stable triplex DNA as a result of interaction between the nucleoside analogs and duplex DNA. And this oligonucleotide inhibited the gene expression in the cultured cell.
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Report
(3 results)
Research Products
(56 results)