| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this study, we designed and synthesized the nucleoside analogs which interact with duplex DNA. Moreover, we aimed to establish the basic technology of the regulation of the gene expression using these nucleoside analogs. We have found that oligonucleotide containing the nucleoside analogs formed the stable triplex DNA as a result of interaction between the nucleoside analogs and duplex DNA. And this oligonucleotide inhibited the gene expression in the cultured cell.
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