Development of efficient synthetic method for the natural product possessing sequential chiral quaternary carbons.
| Project/Area Number |
20790020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
KAWAI Nobuyuki Kyoto Pharmaceutical University, 薬学部, 助教 (10411034)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 合成化学 / 癌 / 薬学 / 有機化学 |
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| Research Abstract |
Synthesis of platencimycin and bicyclolactone unit of shimalacton possessing sequential quaternary carbons was investigated. In the former, the tri cyclic compound possessing the desired quaternary carbon was obtained with a high selectivity by heating the precursor which consists the diene unit possessing cyclopentane and the dienophile unit possessing tri-substituted alkene at 200℃. In the latter, by utilizing transannular cyclization of the lactone, the cyclopentane derivative was obtained as a sole product with the desired stereochemistry.
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Report
(3 results)
Research Products
(22 results)
