Development of Tandem Reactions for Synthesis of Heterocyclic Compounds via Palladium-Catalyzed 1,2-Addition
| Project/Area Number |
20790021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
KURIYAMA Masami Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (40411087)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 合成化学 / パラジウム / カルベン / 付加反応 / 複素環 / フタライド |
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| Research Abstract |
Novel thioether-imidazolinium carbene ligands were developed and the palladium/thioether-imidazolinium chloride system was proved to be an efficient catalyst for the 1,2-addition reactions of organoboron reagents to aldehydes. This reaction system can be an environmentally benign synthetic method because of its tolerance for aqueous reaction conditions. In addition, efficient synthesis of 3-arylphthalides via palladium-catalyzed 1,2-addition with thioether-imidazolinium carbene ligands was successfully achieved.
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Report
(3 results)
Research Products
(18 results)
