Development of efficient and sequential bond-forming reaction using diverse reactivity of conjugated imines
| Project/Area Number |
20790023
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
UEDA Masafumi Kobe Pharmaceutical University, 薬学部, 講師 (00340935)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 合成化学 / ラジカル反応 / 共役イミン / ヒドロキシアルキル化 / 酸化 / トリエチルボラン / ドミノ反応 / ヒドロキシスルフィド / チオール |
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| Research Abstract |
We are interested in the diverse reactivity of conjugated imines and successfully developed novel domino reactions involving regioselective radical addition reaction and subsequent hydroxylation with aerobic oxygen. Hydoxysulfenylation reaction via carbon-sulfur bond formation and hydroxylation and Hydoxyalkylation reaction via carbon-carbon bond formation and hydroxylation have been developed.
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Report
(3 results)
Research Products
(16 results)
