Regioselective Carbometalation of Alkenes Using a Unique Feature of Cationic Scandium Species

• Project/Area Number: 20790026
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemical pharmacy
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAKIMOTO Masanori The Institute of Physical and Chemical Research, 侯有機金属化学研究室, 専任研究員 (50312377)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 触媒反応 / 希土類 / 有機アルミニウム / アルケン / アルキン / カルボメタル化

Research Abstract

A scandium-based catalyst system for the regio^- and stereoselective carboalumination of alkenes and internal alkynes having an ether tether group have been developed in this research. In most cases, the achieved selectivities are unique to the present catalyst system and could not be achieved by previously known catalysts.

Research Products

• [Journal Article] Scandium-Catalyzed Regio- and Stereospecific Methylalumination of Silyloxy/Alkoxy-Substituted Alkynes and Alkenes (2009)
  • Author(s): M. Takimoto, S. Usami, Z. Hou
  • Journal Title: J. Am. Chem. Soc. 131 Pages: 18266-18268
  • Peer Reviewed
• [Journal Article] Scandium-Catalyzed Regio- and Stereospecific Methylalumination of Sily loxy/Alkoxy-Substituted Alkynes and Alkenes (2009)
  • Author(s): Masanori Takimoto
  • Journal Title: Journal of the American Chemical Society 131 Pages: 18266-18268
  • Peer Reviewed
• [Presentation] Scandium-Catalyzed Regioselective Methylalumination of Internal Alkynes and Alkenes (2009)
  • Author(s): Masanori Takimoto, Saori Usami, Zhaomin Hou
  • Organizer: The 11th International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-11-11
• [Presentation] Scandium-Catalyzed Regioselective Methylalumination of Internal Alkynes and Alkenes (2009)
  • Author(s): Masanori Takimoto
  • Organizer: The 11^<th> International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-11-11
• [Presentation] スカンジウム触媒による内部アルキンの位置選択的メチルアルミ化反応 (2009)
  • Author(s): 瀧本真徳、侯召民
  • Organizer: 第89日本化学会春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] スカンジウム触媒によるアルケンの位置選択的メチルアルミ化反応 (2009)
  • Author(s): 宇佐美沙織、瀧本真徳、侯召民
  • Organizer: 第89日本化学会春季年会
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-29
• [Presentation] スカンジウム触媒を用いるアルキン及びアルケンの選択的カルボアルミ化反応の開発 (2008)
  • Author(s): 瀧本真徳、宇佐美沙織、侯召民
  • Organizer: 第34回反応と合成の進歩シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2008-11-05
• [Remarks]
  • URL: http://www.riken.jp/lab-www/organometallic/index.html
• [Remarks]
  • URL: http://www.rikenresearch.riken.jp/eng/research/6175