| Project/Area Number |
20790027
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
YOSHIOKA Eito Hyogo University of Health Sciences, 薬学部, 助教 (80435685)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生体関連物質 / 癌診断用PETプローブ / ベンザイン / [2+2]型反応 / 多成分連結反応 / クロメン類 / クマリン類 / ラジカル反応 / 求電子ラジカル / 光反応 / 有機化学 / 合成化学 / 連続反応 / アミノフェノール / サリチルアルデヒド / PET / クリック化学 / ベンゾトリアゾール |
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| Research Abstract |
I paid attention to the positron-emitting radionuclide, especially gallium-68 and carbon-11, and developed the following reactions using an unstable chemical species such as aryne and radical for the label based on high-speed reactions. In addition, I developed the oxidation-reduction reaction using the photocatalyst for capture of CO_2.
First, to develop gallium-68 probe, I studied aryne based Huisgen-type reaction under the metal-free condition and desired benztriazole was obtained in excellent yield. I also reported the [2+2] type reaction, insertion of aryne into the C=O π-bond of formamides, and the subsequent trapping process of the benzoxetene intermediate with dialkylzincs. In addition, under mild condition, I reported the multi-component coupling reaction leading chromenes, coumarins and xanthenes via the insertion into π-bond of DMF. Moreover, I reported the cascade addition-cyclization-trapping reaction involving the unfavorable mismatched interaction of nucleophilic radicals, together with the control of enantioselectivities. And I reported the results of experiments to prove the utility of the polycrystalline TiO_2 (P25) in the hydrogenation of aromatic ketones.
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