| Project/Area Number |
20790031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
NISHIO Tadashi Keio University, 薬学部, 助教 (80401892)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 臨床分析科学 / 新生児マススクリーニング / 先天性副腎過形成症 / 先天性甲状腺機能低下症 / LC-MS / 誘導体化 / 温度応答性クロマトグラフィー / クレチン症 / トリヨードサイロニン / 治療薬物モニタリング / プロポフォール / 17α-ヒドロキシプロゲステロン / 17α-ヒドロキシプレグネノロン / LC-ESI-MS / MS / 低体重児 |
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| Research Abstract |
High-sensitive and reliable analytical methods are required for newborn mass screening. As for low-birth weight infants, high false positive rate of diseases are observed in the first screening assay. Based on this background, we developed the effective analytical methods of biomarker, utilizing the igh-performance liquid chromatography-mass spectrometry (LC-MS). Furthermore, we applied the temperature-responsive chromatography to quantification of anesthetic agents in biological fluids. In this chromatography system, only water is used as the mobile phase, and there are many advantages from the point of view of the green chemistry.
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