AGE-RAGE interaction as a target for drug design against diabetes complications
Project/Area Number |
20790034
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Physical pharmacy
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Research Institution | Osaka University |
Principal Investigator |
YOSHIDA Takuya Osaka University, 薬学研究科, 助教 (00294116)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 構造生物学 / AGE / RAGE / 立体構造 / 創薬 |
Research Abstract |
We have analyzed the conformational dynamics of the variable-type domain of RAGE (Receptor for AGE), which has been revealed to contain the binding site of AGE. Based on the results of NMR and MD calculation, a combination of virtual and in vitro screening was carried out to find suitable chemical compounds to interfere with the AGE-RAGE binding. As a result, chemical compounds were identified as candidates for RAGE inhibitor.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Solution structure of the variable-type domain of the receptor for advanced glycation end products: new insight into AGE-RAGE interaction.2008
Author(s)
Matsumoto S, Yoshida T, Murata H, Harada S, Fujita N, Nakamura S, Yamamoto Y, Watanabe T, Yonekura H, Yamamoto H, Ohkubo T, Kobayashi Y.
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Journal Title
Biochemistry 47
Pages: 12299-311
Related Report
Peer Reviewed
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