Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Research Abstract |
We have analyzed the conformational dynamics of the variable-type domain of RAGE (Receptor for AGE), which has been revealed to contain the binding site of AGE. Based on the results of NMR and MD calculation, a combination of virtual and in vitro screening was carried out to find suitable chemical compounds to interfere with the AGE-RAGE binding. As a result, chemical compounds were identified as candidates for RAGE inhibitor.
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