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Influence of tumor lymphangiogenesis on tumor-targeting liposomal DDS

Research Project

Project/Area Number 20790041
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

SHIMIZU Kosuke  University of Shizuoka, 薬学部・大学院・薬学研究科, 助教 (30423841)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsドラッグデリバリー / DDS / リポソーム / がん / リンパ管新生 / EPR効果
Research Abstract

It is known that the microenvironment surrounding tumor cells is continuously changed. Recent studies have demonstrated that lymphangiogenesis, an event involving construction of new lymphatic vessels, frequently occurs in tumor tissue and contributes to lymph node metastasis of tumors. Since lymphatic vessels in tissues function as a drainage system, tumor lymphangiogenesis would be considered to affect the liposomal accumulation in the tumor. In this study, we found that lymphangiogenesis caused the decrease in tumor accumulation of liposomes, and demonstrated the influence of tumor lymphangiogenesis on tumor-targeting liposomal DDS.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (70 results)

All 2011 2010 2009 2008 Other

All Journal Article (26 results) (of which Peer Reviewed: 24 results) Presentation (42 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Anti-angiogenic activity and intracellular distribution of epigallocatechin-3-gallate analogs.2011

    • Author(s)
      Piyaviriyakul S, Shimizu K, Asakawa T, Kan T, Siripong P, Oku N.
    • Journal Title

      Biol Pharm Bull. 34

      Pages: 396-400

    • NAID

      130000657819

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PET imaging of brain cancer with positron emitter-labeled liposomes2011

    • Author(s)
      Naoto Oku, et al.
    • Journal Title

      Int.J.Pharm.

      Volume: 403 Pages: 170-177

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-angiogenic Activity and Intracellular Distribution of Epigallocatechin-3-gallate Analogs2011

    • Author(s)
      Suratsawadee Piyaviriyakul, et al.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 34 Pages: 396-400

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PET imaging of nobiletin based on a practical total synthesis2011

    • Author(s)
      Tomohiro Asakawa, et al.
    • Journal Title

      Chem.Commun.(Camb)

      Volume: 47 Pages: 2868-2870

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise synthesis of catechin probes enabling analysis and imaging of EGCg2011

    • Author(s)
      Atsushi Yoshida, et al.
    • Journal Title

      Chem.Commun.(Camb)

      Volume: 47 Pages: 1794-1796

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PET imaging of brain cancer with positron emitter-labeled liposomes.2010

    • Author(s)
      Oku N, Yamashita M, Katayama Y, Urakami T, Hatanaka K, Shimizu K, Asai T, Tsukada H, Akai S, Kanazawa H.
    • Journal Title

      Int J Pharm. 403

      Pages: 170-177

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice.2010

    • Author(s)
      Shimizu K, Ida T, Tsutsui H, Asai T, Otsubo K, Oku N.
    • Journal Title

      J.Agric.Food Chem. 58

      Pages: 11218-11225

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.2010

    • Author(s)
      Shimizu K, Osada M, Takemoto K, Yamamoto Y, Asai T, Oku N.
    • Journal Title

      J.Control.Release 141

      Pages: 208-215

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice.2010

    • Author(s)
      Shimizu K, Kinouchi Shimizu N, Hakamata W, Unno K, Asai T, Oku N.
    • Journal Title

      Biol.Pharm.Bull. 33

      Pages: 117-121

    • NAID

      130000140203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy.2010

    • Author(s)
      Murase Y, Asai T, Katanasaka Y, Sugiyama T, Shimizu K, Maeda N, Oku N.
    • Journal Title

      Cancer Lett. 287

      Pages: 165-171

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice2010

    • Author(s)
      Kosuke Shimizu, et al.
    • Journal Title

      J.Agric.Food Chem.

      Volume: 58 Pages: 11218-11225

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy2010

    • Author(s)
      Yuki Murase, et al.
    • Journal Title

      Cancer Lett. 287

      Pages: 165-71

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice2010

    • Author(s)
      Kosuke Shimizu, et al.
    • Journal Title

      Biol.Pharm.Bull. 33

      Pages: 117-121

    • NAID

      130000140203

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane2010

    • Author(s)
      Kosuke Shimizu, et al.
    • Journal Title

      J.Control.Release 141

      Pages: 208-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.2009

    • Author(s)
      Urakami T, Kawaguchi AT, Akai S, Hatanaka K, Koide H, Shimizu K, Asai T, Fukumoto D, Harada N, Tsukada H, Oku N.
    • Journal Title

      Artif.Organs 33

      Pages: 164-168

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In Vivo Distribution of Liposome-encapsulated Hemoglobin Determined by Positron Emission Tomography2009

    • Author(s)
      Takeo Urakami, et al.
    • Journal Title

      Artif.Organs 33

      Pages: 164-168

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elucidation of accelerated blood clearance phenomenon caused by repeat injection of PEGylated nanocarriers2009

    • Author(s)
      Hiroyuki Koide, et al.
    • Journal Title

      Yakugaku Zasshi 129

      Pages: 1445-1451

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-in dol-2-one, SU5416.2008

    • Author(s)
      Katanasaka Y, Ida T, Asai T, Shimizu K, Koizumi F, Maeda N, Baba K, Oku N.
    • Journal Title

      Cancer Lett. 270

      Pages: 260-268

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.2008

    • Author(s)
      Shimizu K, Kinouchi Shimizu N, Asai T, Tsukada H, Oku N.
    • Journal Title

      Biol.Pharm.Bull. 31

      Pages: 847-851

    • NAID

      110006663939

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC.2008

    • Author(s)
      Asai T, Miyazawa S, Maeda N, Hatanaka K, Katanasaka Y, Shimizu K, Shuto S, Oku N.
    • Journal Title

      Cancer Sci. 99

      Pages: 1029-1033

    • NAID

      10024006453

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronopharmacologic cancer treatment with and angiogenic vessel-targeted liposomal drug2008

    • Author(s)
      Kosuke Shimizu, et.al.
    • Journal Title

      Biol. Pharm. Bull 31

      Pages: 95-98

    • NAID

      110006569981

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced experimental tumor metastasis with age in senescence-accelerated mouse2008

    • Author(s)
      Kosuke Shimizu, et.al.
    • Journal Title

      Biol. Pharm 31

      Pages: 847-851

    • NAID

      110006663939

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC2008

    • Author(s)
      Tomohiro Asai, et.al.
    • Journal Title

      Cancer Sci 99

      Pages: 1029-1033

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake2008

    • Author(s)
      Hiromichi Imanaka, et.al.
    • Journal Title

      Biol. Pharm. Bull 31

      Pages: 400-404

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3, 5-dimethyl-1H-pyrrol-2-ylmethylene)-1, 3-dihydro-indol-2-one, SU54162008

    • Author(s)
      Yasufumi Katanasaka, et.al.
    • Journal Title

      Cancer Lett 270

      Pages: 260-268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Argonaute2ノックダウンによる腫瘍新生血管傷害療法の開発2008

    • Author(s)
      畑中剣太朗, ら
    • Journal Title

      YAKUGAKU ZASSHI 128

      Pages: 240-247

    • Related Report
      2008 Annual Research Report
  • [Presentation] Asialo-EPO修飾PEGリポソームによる脳虚血再灌流障害治療2011

    • Author(s)
      福田達也, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      グランシップ・ツインメッセ・静岡県立大学
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] RT-DDSを応用した新規スギ花粉症治療法の開発2011

    • Author(s)
      松木孝太, ら
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      グランシップ・ツインメッセ・静岡県立大学
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] RT-DDSを応用した新規スギ花粉治療法の開発2010

    • Author(s)
      横山智紀, ら
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺がん治療を目的とした新規レクチン修飾リポソームの開発2010

    • Author(s)
      大橋健人, ら
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規カテキン誘導体の血管新生抑制効果の解明2010

    • Author(s)
      Suratsawadee Piyaviriyakul, et al.
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2010
    • Place of Presentation
      静岡県立大学
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] EGCgの効率的合成法の開発、プローブ化、機能と動態の解明2010

    • Author(s)
      浅川倫宏, ら
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都テルサ
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Positron imaging of biodistribution of [11C]Me-EGCg2010

    • Author(s)
      Kosuke Shimizu, et al.
    • Organizer
      ICOS 2010 The 4th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2010-10-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Practical synthesis of nobiletin and its PET imaging study2010

    • Author(s)
      Aiki Hiza, et al.
    • Organizer
      ICOS 2010 The 4th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2010-10-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Investigation of EGCg distribution in HUVECs2010

    • Author(s)
      Suratsawadee Piyaviriyakul, et al.
    • Organizer
      ICOS 2010 The 4th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2010-10-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzensulfonyl(Ns) protecting group2010

    • Author(s)
      Tomohiro Asakawa, et al.
    • Organizer
      ICOS 2010 The 4th International Conference on O-CHA (Tea) Culture and Science
    • Place of Presentation
      グランシップ(静岡)
    • Year and Date
      2010-10-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Asialo-erythropoietin修飾PEGリポソームの開発と脳虚血再灌流障害への応用2010

    • Author(s)
      尾山大, ら
    • Organizer
      第26回DDS学会
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍リンパ管新生が及ぼす薬物ナノキャリア腫瘍移行性への影響2010

    • Author(s)
      清水広介, ら
    • Organizer
      第74回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 腫瘍リンパ管新生が及ぼす薬物ナノキャリア腫瘍移行性への影響2010

    • Author(s)
      清水広介, ら
    • Organizer
      第74回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      名古屋大学医学部
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍リンパ管新生がリポソームのがん集積性に与える影響2010

    • Author(s)
      清水広介, ら
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-12
    • Related Report
      2010 Final Research Report
  • [Presentation] リポソームDDS技術を用いた脳虚血再灌流障害治療2010

    • Author(s)
      石井貴之, ら
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島あわぎんホール
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍リンパ管新生がリポソームのがん集積性に与える影響2010

    • Author(s)
      清水広介, ら
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島あわぎんホール
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] リポソーム腫瘍内挙動に対するリンパ管新生の影響2010

    • Author(s)
      山口里美, ら
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] リポソーム腫瘍内挙動に対するリンパ管新生の影響2010

    • Author(s)
      山口里美, ら
    • Organizer
      第130年会日本薬学会
    • Place of Presentation
      ホテルグランヴィア岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳虚血再灌流障害治療に向けたリボソームDDS技術の開発2010

    • Author(s)
      石井貴之, ら
    • Organizer
      第130年会日本薬学会
    • Place of Presentation
      ホテルグランヴィア岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規カテキン誘導体の血管新生抑制作用の検討2010

    • Author(s)
      Suratsawadee Piyaviriyakul, ら
    • Organizer
      第130年会日本薬学会
    • Place of Presentation
      岡山桃太郎アリーナ
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Liposomal tumor targeting and tumor lymphangiogenesis.2010

    • Author(s)
      Kosuke Shimizu, et al.
    • Organizer
      LRD/LLMB 2010 Conference
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthetic Polymer Nanoparticles that Capture the Antigen Protein of Japanese Cedar Pollen Allergy2010

    • Author(s)
      Yusuke Yonamine, et al.
    • Organizer
      ACS Spring 2010 National Meeting
    • Place of Presentation
      San Francisco, U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pharmacokinetic PET studies of liposomal siRNA2010

    • Author(s)
      Tomohiro Asai, et al.
    • Organizer
      LRD/LLMB 2010 Conference
    • Place of Presentation
      University of British Columbia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Treatment of cerebral ischemia-reperfusion injury by liposomal drug delivery system2010

    • Author(s)
      Takayuki Ishii, et al.
    • Organizer
      LRD/LLMB 2010 Conference
    • Place of Presentation
      University of British Columbia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Liposomal tumor targeting and tumor lymphangiogenesis2010

    • Author(s)
      Kosuke Shimizu, et al.
    • Organizer
      LRD/LLMB 2010 Conference
    • Place of Presentation
      University of British Columbia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of lymphangiogenesis in tumor-targeting liposomal delivery.2009

    • Author(s)
      Satomi Yamaguchi, et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      London, UK
    • Year and Date
      2009-12-14
    • Related Report
      2010 Final Research Report
  • [Presentation] PET technology to determine pharmacokinetics of liposomal siRNA2009

    • Author(s)
      Tomohiro Asai, et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      University of London
    • Year and Date
      2009-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Involvement of lymphangiogenesis in tumor-targeting liposomal delivery2009

    • Author(s)
      Satomi Yamaguchi, et al.
    • Organizer
      4th International Liposome Society Conference
    • Place of Presentation
      University of London
    • Year and Date
      2009-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Application of phosphatidylinositol as a functional food for health and longevity focused on anti-obesity2009

    • Author(s)
      Naoto Oku, et al.
    • Organizer
      2nd International Conference on Health and Longevity Sciences
    • Place of Presentation
      University of Shizuoka
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism of Temperature-dependent Antifungal Activity of AmBisome2009

    • Author(s)
      Kosuke Shimizu, et al.
    • Organizer
      36th Annual Meeting & Exposition of Controlled Release Society
    • Place of Presentation
      Bella Center
    • Year and Date
      2009-07-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] リンパ管新生が及ぼすリポソームの腫瘍集積性への影響2009

    • Author(s)
      山口里美, ら
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] リンパ管新生が及ぼすリポソームの腫瘍集積性への影響2009

    • Author(s)
      山口里美, ら
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 機能性リン脂質Phosphatidylinositolの体内動態解析と肥満抑制効果の検討2009

    • Author(s)
      清水広介, ら
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎新聞文化ホール
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] リンパ管新生が及ぼすリポソームの腫瘍内挙動への影響2008

    • Author(s)
      山口里美, ら
    • Organizer
      Biochemistry and Molecular Biology 2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] リンパ管新生が及ぼすリポソームの腫瘍内挙動への影響2008

    • Author(s)
      山口里美, ら
    • Organizer
      Biochemistry and Molecular Biology 2008
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tumor-targeting liposomal DDS and lymphagiogenesis.2008

    • Author(s)
      Kosuke Shimizu, et al.
    • Organizer
      11th Liposome Research Days Conference
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-07-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Cancer antiangiogenic therapy using tumor vasculature-targeted liposomes encapsulating SU54162008

    • Author(s)
      Tomoko Ida, et.al.
    • Organizer
      11^<th> Liposome Research Days Conference
    • Place of Presentation
      横浜シンポジア(横浜)
    • Year and Date
      2008-07-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tumor-targeting Liposomal DDS and Lymphangiogenesis2008

    • Author(s)
      Kosuke Shimizu, et.al.
    • Organizer
      11^<th> Liposome Research Days Conference
    • Place of Presentation
      横浜シンポジア(横浜)
    • Year and Date
      2008-07-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeted delivery of SU5416 and antiangiogenic cancer therapy using tumor vasculature-targeted liposomes2008

    • Author(s)
      Tomoko Ida, et.al.
    • Organizer
      35th Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Hilton New York (New York)
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] リポソームの腫瘍受動標的化におけるリンパ管新生の影響2008

    • Author(s)
      清水広介, ら
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-30
    • Related Report
      2010 Final Research Report
  • [Presentation] リポソームの腫瘍受動標的化におけるリンパ管新生の影響2008

    • Author(s)
      清水広介, ら
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      六本木アカデミーヒルズ(東京)
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腫瘍新生血管標的化リポソームを用いた血管新生阻害剤の効率的送達によるがん治療2008

    • Author(s)
      井田智子, ら
    • Organizer
      日本薬剤学会第23回年会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Book] 機能性DDSキャリアの製剤設計(岡田弘晃監修)2008

    • Author(s)
      清水広介, ら
    • Total Pages
      321
    • Publisher
      むシーエムシー出版
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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