STAP-2 modulates activation-induced cell death in T-cell
Project/Area Number |
20790050
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
|
Research Institution | Hokkaido University |
Principal Investigator |
SEKINE Yuichi Hokkaido University, 大学院・薬学研究院, 助教 (20396295)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | T細胞 / アポトーシス / AICD(活性化誘導性細胞死) / アダプター分子 / STAP-2 / 自己免疫疾患 / Caspase / シグナル伝達 / アダプタ-分子 |
Research Abstract |
Adaptor protein STAP-2 is a multifunctional molecule which regulates cellular signaling negatively or positively in immune responses. In this study, I investigated the functional mechanisms of STAP-2 in T-cell activation-induced cell death(AICD). It is revealed that STAP-2 enhances T-cell apoptosis, so STAP-2 plays a role in T-cell AICD.
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Report
(3 results)
Research Products
(27 results)