| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Interferon-α and-β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors. DAXX expression has been reported to be essential for the inhibitory effect of type I interferons, although the mechanisms involved remain unclear. Here, we examined the role of DAXX in the gp130/STAT3-dependent cell growth/survival signals. We found that DAXX suppresses gp130-mediated cell growth and survival thorough the transcriptional repression of genes.
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