Analysis of DAXX-mediated cell death in pro-B cell line
| Project/Area Number |
20790051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
MUROMOTO Ryuta Hokkaido University, 大学院・薬学研究院, 助教 (30455597)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | インターフェロン / DAXX / アポトーシス / STAT3 / 免疫学 / 分子生物学 / サイトカイン / TYK2 / 細胞生物学 / Daxx / Tyk2 |
|---|
| Research Abstract |
Interferon-α and-β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors. DAXX expression has been reported to be essential for the inhibitory effect of type I interferons, although the mechanisms involved remain unclear. Here, we examined the role of DAXX in the gp130/STAT3-dependent cell growth/survival signals. We found that DAXX suppresses gp130-mediated cell growth and survival thorough the transcriptional repression of genes.
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Report
(3 results)
Research Products
(44 results)
