Physiological Function of PI 3-phosphate 5-kinase
Project/Area Number |
20790054
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Akita University |
Principal Investigator |
TAKASUGA Shunsuke Akita University, 大学院・医学系研究科, 助教 (90375262)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 細胞生物学 / イノシトールリン脂質 / リン脂質 / 遺伝子改変マウス / 脂質 / 発生・分化 |
Research Abstract |
PI 3, 5-bisphosphate is a most recently discovered PIP 2 isomer, produced via phosphorylation of PI 3-phosphate by PIP kinases. To understand the physiological function of PI 3,5-bisphosphate in adult mice, we recently generated a knockout mouse strain. Deletion of this molecule causes an excessive vacuolation in brain and a premature death. Our results indicate that this molecule is essential for central nervous system.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] The PtdIns(3, 4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death2010
Author(s)
Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T.
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Journal Title
N a t u r e 465
Pages: 497-501
Related Report
Peer Reviewed
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[Journal Article] The PtdIns(3,4)P_2-phosphatase INPP4A is a suppressor of excitotoxic neuronal death2010
Author(s)
Sasaki J., Kofuji S., Itoh R., Momiyama T., Takayama K., Murakami H., Chida S., Tsuya Y., Takasuga S, Eguchi S., Asanuma K., Horie Y., Miura K., Davies E., Mitchell C., Yamazaki M., Hirai H., Takenawa T., Suzuki A., Sasaki T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.2009
Author(s)
Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
Author(s)
Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sane matsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
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Journal Title
Science 324
Pages: 384-387
Related Report
Peer Reviewed
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[Journal Article] Sequential Regulation of DOCK2 Dynamics by Two Phospholipids during Neutrophil Chemotaxis2009
Author(s)
Nishikimi A, Fukuhara H, Su W , Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shi basaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
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Related Report
Peer Reviewed
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