| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Exchanging materials between outer environments is essential for cells to maintain their homeostasis. Cells accomplish it by utilizing vesicular trafficking called endocytosis and exocytosis. Rab proteins are part of the Ras superfamily of small GTPases, which works switch molecules by undergoing a cycle between GDP-bound and GTP-bound form. Our research is focused on the molecular mechanism how Rab5, one of Rab family, regulates endocytosis. We have elucidated that multiple Rab proteins are activated by RIN family proteins.
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