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The mechanism of endocytosis regulated by orchestrated activations of multiple small GTPases

Research Project

Project/Area Number 20790056
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

KAJIHO Hiroaki  The University of Tokyo, 大学院・薬学系研究科, 助教 (70401221)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsエンドサイトーシス / メンブレントラフィック / 低分子量G蛋白質 / Rab / GEF
Research Abstract

Exchanging materials between outer environments is essential for cells to maintain their homeostasis. Cells accomplish it by utilizing vesicular trafficking called endocytosis and exocytosis. Rab proteins are part of the Ras superfamily of small GTPases, which works switch molecules by undergoing a cycle between GDP-bound and GTP-bound form. Our research is focused on the molecular mechanism how Rab5, one of Rab family, regulates endocytosis. We have elucidated that multiple Rab proteins are activated by RIN family proteins.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (29 results)

All 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (20 results)

  • [Journal Article] Filamin associates with stress signaling kinases MKK7 and MKK4 and regulates JNK activation.2010

    • Author(s)
      Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H.
    • Journal Title

      THE BIOCHEMICAL JOURNAL 427

      Pages: 237-245

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CrxOS maintains the self-renewal capacity of murine embryonic stem cells.2009

    • Author(s)
      Saito R, Yamasaki T, Nagai Y, Wu J, Kajiho H, Yokoi T, Noda E, Nishina S, Niwa H, Azuma N, Katada T, Nishina H.
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390

      Pages: 1129-1135

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.2009

    • Author(s)
      Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T.
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 381

      Pages: 439-432

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signaling pathway.2009

    • Author(s)
      Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H.
    • Journal Title

      J Biochem. 145

      Pages: 345-354

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CrxOS maintains the self-renewal capacity of murine embryonic stem cells2009

    • Author(s)
      Saito R., et al.
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 390

      Pages: 1129-1135

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome2009

    • Author(s)
      KOBAYASHI T., et al.
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 381

      Pages: 439-442

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.2008

    • Author(s)
      Yoshikawa M*, Kajiho H*, Sakurai K, Minoda T, Nakagawa S, Kontani K, Katada T.
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372

      Pages: 168-172

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tyr-phosphorylation signals translocate RIN3, the small GTI ase Rab5-GEF, to early endocytic vesicles.2008

    • Author(s)
      Yoshikawa M, et.al.
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372

      Pages: 168-172

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockage by SP600125 of Fcepsilon receptor-induced degranul ation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.2008

    • Author(s)
      Tanemura S, et.al.
    • Journal Title

      THE JOURNAL OF BIOCHEMISTRY 145

      Pages: 345-354

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rab5 GEF RINファミリーの機能解析2010

    • Author(s)
      梶保博昭, 堅田利明
    • Organizer
      第1回膜輸送複合体 若手の会
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-03-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低分子量G蛋白質Rab5GEF RINファミリーによる小胞輸送の機構解析2010

    • Author(s)
      梶保博昭、池田誠一、福島槙一、堅田利明
    • Organizer
      第一回GPCM
    • Place of Presentation
      東京
    • Year and Date
      2010-02-07
    • Related Report
      2009 Final Research Report
  • [Presentation] RIN2による Cicular ruffle 形成機構2010

    • Author(s)
      梶保博昭, 堅田利明
    • Organizer
      第一回GPCM
    • Place of Presentation
      東京大学大学院薬学系研究科
    • Year and Date
      2010-02-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] RIN2の circular ruffle 形成の分子機構における役割の解明2009

    • Author(s)
      池田誠一, 梶保博昭, 堅田利明
    • Organizer
      第8回次世代を担う若手 ファーマ・バイオフォーラム2009
    • Place of Presentation
      名古屋市立大学
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低分子量G蛋白質Rab5 GEFであるRIN3とアクチン結合蛋白質 Cortactin の相互作用の解析2009

    • Author(s)
      吉川学、梶保博昭、堅田利明
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 紫外線照射時のJNK活性化制御機構におけるRassf7の関与2009

    • Author(s)
      蛯原有紗、高橋真也、櫻井京子、梶保博昭、仁科博史、堅田利明
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] アミノ酸シグナルにおけるRagの機能解析2009

    • Author(s)
      福山征光、下村裕美、長屋涼太郎、春日秀文、田杭靖丈、壱岐和哉、伊藤有佳子、梶保博昭、紺谷圏二、堅田利明
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] P-body形成の生理的意義とその分子機構の解析2009

    • Author(s)
      櫻井京子、高橋真也、蛯原有紗、梶保博昭、堅田利明
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] RIN3のリン酸化状態によるRab5サブファミリーへのGEF活性調節機構(WS口頭発表)2009

    • Author(s)
      梶保博昭、堅田利明
    • Organizer
      文部科学省特定領域研究「細胞情報ネットワークを統合するg蛋白質シグナル研究の新展開」班会議
    • Place of Presentation
      南房総・富浦
    • Year and Date
      2009-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] RIN3のリン酸化状態によるRab5サブファミリーへのGEF活性調節機構2009

    • Author(s)
      梶保博昭, 堅田利明
    • Organizer
      文部科学省特定領域研究「細胞情報ネットワークを統合するG蛋白質シグナル研究の新展開」班会議
    • Place of Presentation
      富浦ロイヤルホテル
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 紫外線照射時のJNK活性化制御機構におけるRASSF7の関与2009

    • Author(s)
      蛯原有紗、高橋真也、梶保博昭、仁科博史、堅田利明
    • Organizer
      文部科学省特定領域研究「細胞情報ネットワークを統合するG蛋白質シグナル研究の新展開」班会議
    • Place of Presentation
      富浦ロイヤルホテル
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] RINファミリーによる低分子量g蛋白質Rab31の活性化機構解析(ポスター発表)2009

    • Author(s)
      梶保博昭、堅田利明
    • Organizer
      定量生物学の会第1回年会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.2008

    • Author(s)
      Hiroaki Kajiho, Manabu Yoshikawa, Kyoko Sakurai, Tomohiro Minoda, Satoshi Nakagawa, Kenji Kontani, Toshiaki Katada [Poster]
    • Organizer
      48th ASCB Annual Meeting
    • Place of Presentation
      米国、サンフランシスコ
    • Year and Date
      2008-12-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Tyr-phosphorylation signals translocate RIN3, the small GTPa se Rab5-GEF, to early endocytic vesicles.2008

    • Author(s)
      Hiroaki Kajiho, Manabu Yosh ikawa, Kyoko Sakurai, Tomoh iro Minoda, Satoshi Nakagaw a, Kenji Kontani, and Toshi aki Katada
    • Organizer
      48th ASCB Annual Meeting
    • Place of Presentation
      Moscone center, USA
    • Year and Date
      2008-12-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] RINファミリーによる低分子量G蛋白質Rab31の活性化機構解析2008

    • Author(s)
      梶保博昭, 櫻井京子, 簑田智博, 中川哲志, 吉川学, 高橋真也, 蛯原有沙, 堅田利明
    • Organizer
      BMB2008
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] エンドサイトーシス過程におけるチロシンリン酸化シグナルによるRab5-GEFRIN3制御の解析2008

    • Author(s)
      吉川学, 梶保博昭, 櫻井京子, 簑田智博, 中川哲志, 高橋真也, 蛯原有沙, 堅田利明
    • Organizer
      BMB2008
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] RIN3のリン酸化/脱リン酸化による低分子量G蛋白質Rab31の活性制御の解明2008

    • Author(s)
      簑田智博, 梶保博昭, 櫻井京子, 中川哲志, 吉川学, 高橋真也, 蛯原有沙, 堅田利明
    • Organizer
      BMB2008
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] インスリン依存的にGLUT4膜移行を制御するRINの機能解析2008

    • Author(s)
      中川哲志, 簑田智博, 吉川学, 梶保博昭, 堅田利明
    • Organizer
      トランスポーター研究会第2回関東部会
    • Place of Presentation
      東京大学武田ホール
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] インスリン依存的にGLUT4膜移行を制御するRINの機能解析2008

    • Author(s)
      中川哲志, 簑田智博, 吉川学, 梶保博昭, 堅田利明
    • Organizer
      ファーマ・バイオフォーラム2008
    • Place of Presentation
      日本薬学会長井記念館
    • Year and Date
      2008-11-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rab5結合蛋白質RIN3の小胞局在化機能解析[文部科学省特定領域研究2008

    • Author(s)
      梶保博昭、吉川学、堅田利明
    • Organizer
      細胞情報ネットワークを統合するg蛋白質シグナル研究の新展開
    • Place of Presentation
      湯沢
    • Year and Date
      2008-09-19
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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