Regulatory mechanisms of cell survival by glutamine transporter in the brain
| Project/Area Number |
20790061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAMICHI Noritaka Kanazawa University, 薬学系, 准教授 (10401895)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 脳・神経 / 脳神経疾患 / 神経科学 / 薬理学 / 輸送担体 |
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| Research Abstract |
To elucidate physiological and pathological role of glutamine transporters (GlnTs) expressed on astrocytes, we examined affects of GlnTs on the resistibility to the oxidative stress in astrocytes or the vulnerability to the neurotoxicity. As a result, it was suggested that GlnTs may be functionally expressed on astrocytes to increase the sensitivity to the oxidative stress in astrocytes or to protect neurons from the neurotoxicity through the release of neurotrophic factors.
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Report
(3 results)
Research Products
(89 results)
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[Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels.2010
Author(s)
Fukumori, R., Nakamichi, N., Takarada, T., Kambe, Y., Matsushima, N., Moriguchi, N., Yoneda, Y.
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Journal Title
J. Pharmacol. Sci. 112(3)
Pages: 273-281
NAID
Related Report
Peer Reviewed
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[Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.2009
Author(s)
Takarada, T., Tamaki, K., Takumi, T., Ogura, M., Ito, Y., Nakamichi, N., Yoneda, Y.
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Journal Title
J. Neurochem. 110(5)
Pages: 1457-1468
Related Report
Peer Reviewed
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[Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism.2009
Author(s)
Nakamichi, N., Ishioka, Y., Hirai, T., Ozawa, S., Tachibana, M., Nakamura, N., Takarada, T., Yoneda, Y.
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Journal Title
J. Neurosci. Res. 87(11)
Pages: 2406-2417
Related Report
Peer Reviewed
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[Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly.2009
Author(s)
Gu, B., Nakamichi, N., Zhang, W.S., Nakamura, Y., Kambe, Y., Fukumori, R., Takuma, K., Yamada, K., Takarada, T., Taniura, H., Yoneda, Y.
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Journal Title
J. Neurosci. Res. 87(9)
Pages: 2145-2156
Related Report
Peer Reviewed
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[Journal Article] Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells.2008
Author(s)
Nakamichi, N., Yoshida, K., Ishioka, Y., Makanga, J.O., Fukui, M., Yoneyama, M., Kitayama, T.
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Journal Title
J. Neurochem. 105(5)
Pages: 1996-2012
Related Report
Peer Reviewed
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[Journal Article] Yoneda, Y.: Upregulation of ciliary neurotrophic factor expression by GABAA receptors in undifferentiated neural progenitors of fetal mouse brain.2008
Author(s)
Fukui, M., Nakamichi, N., Yoneyama, M., Yoshida, K., Ozawa, S., Kitayama, T., Nakamura, N., Taniura, H.
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Journal Title
J. Neurosci. Res. 86(12)
Pages: 2615-2623
Related Report
Peer Reviewed
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[Journal Article] Insensitivity to glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors in association with delayed mitochondrial membrane potential disruption in cultured rat cortical neurons.2008
Author(s)
Kambe, Y., Nakamichi, N., Georgiev, D.D., Nakamura, N., Taniura, H., Yoneda, Y.
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Journal Title
J. Neurochem. 105(5)
Pages: 1886-1900
Related Report
Peer Reviewed
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[Journal Article] Promotion of neuronal differentiation through activation of NMDA receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex.2008
Author(s)
Yoneyama, M., Nakamichi, N., Fukui, M., Kitayama, T., Georgiev, D.D., Makanga, J.O., Nakamura, N., Taniura, H., Yoneda, Y.
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Journal Title
J. Neurosci. Res 86(11)
Pages: 2392-2402
Related Report
Peer Reviewed
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[Journal Article] Modulation of cellular proliferation and differentiation through GABAB receptors expressed by undifferentiated neural progenitor cells isolated from fetal mouse brain.2008
Author(s)
Fukui, M., Nakamichi, N., Yoneyama, M., Ozawa, S., Fujimori, S., Takahata, Y., Nakamura, N., Taniura, H., Yoneda, Y.
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Journal Title
J. Cell. Physiol. 216(2)
Pages: 507-519
Related Report
Peer Reviewed
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[Presentation] Functional expression of carnitine/organic cation transporter OCTN1 (SLC22A4) in mouse small intestine.2009
Author(s)
Shimizu, T., Sugiura, T., Nakamichi, N., Wakayama, T., Iseki, S., Kubo, Y., Tamai, I., Tsuji, A., Kato, Y.
Organizer
日本薬物動態学会第24回年会
Place of Presentation
国立京都国際会館(京都)
Related Report
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[Presentation] Glutamine transporter expressed by glial cells in glutamate neurotoxicity.2009
Author(s)
Iemata, M., Ogura, M., Taniura, H., Nakamichi, N., Takarada, T., Yoneda, Y.
Organizer
The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
Place of Presentation
Busan Exhibition and Convention Center (Korea)
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