Regulatory mechanisms of cell survival by glutamine transporter in the brain

• Project/Area Number: 20790061
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: NAKAMICHI Noritaka Kanazawa University, 薬学系, 准教授 (10401895)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 脳・神経 / 脳神経疾患 / 神経科学 / 薬理学 / 輸送担体

Research Abstract

To elucidate physiological and pathological role of glutamine transporters (GlnTs) expressed on astrocytes, we examined affects of GlnTs on the resistibility to the oxidative stress in astrocytes or the vulnerability to the neurotoxicity. As a result, it was suggested that GlnTs may be functionally expressed on astrocytes to increase the sensitivity to the oxidative stress in astrocytes or to protect neurons from the neurotoxicity through the release of neurotrophic factors.

Research Products

• [Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. (2010)
  • Author(s): Fukumori, R., Nakamichi, N., Takarada, T., Kambe, Y., Matsushima, N., Moriguchi, N., Yoneda, Y.
  • Journal Title: J. Pharmacol. Sci. 112(3) Pages: 273-281
  • NAID: 10027744270
  • Peer Reviewed
• [Journal Article] Induced tolerance to glutamate neurotoxicity through down-regulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons (2010)
  • Author(s): Yuki Kambe, et al.
  • Journal Title: Journal of Neuroscience Research (in press)
  • Peer Reviewed
• [Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca^<2+> influx through acquired and native N-methyl-D-aspartate-receptor channels (2010)
  • Author(s): Ryo Fukumori, et al.
  • Journal Title: Journal of Pharmacological Sciences 112(3) Pages: 273-281
  • Peer Reviewed
• [Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus. (2009)
  • Author(s): Takarada, T., Tamaki, K., Takumi, T., Ogura, M., Ito, Y., Nakamichi, N., Yoneda, Y.
  • Journal Title: J. Neurochem. 110(5) Pages: 1457-1468
  • Peer Reviewed
• [Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism. (2009)
  • Author(s): Nakamichi, N., Ishioka, Y., Hirai, T., Ozawa, S., Tachibana, M., Nakamura, N., Takarada, T., Yoneda, Y.
  • Journal Title: J. Neurosci. Res. 87(11) Pages: 2406-2417
  • Peer Reviewed
• [Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly. (2009)
  • Author(s): Gu, B., Nakamichi, N., Zhang, W.S., Nakamura, Y., Kambe, Y., Fukumori, R., Takuma, K., Yamada, K., Takarada, T., Taniura, H., Yoneda, Y.
  • Journal Title: J. Neurosci. Res. 87(9) Pages: 2145-2156
  • Peer Reviewed
• [Journal Article] Neurogenesis mediated by GABA and glutamate signaling. (2009)
  • Author(s): Nakamichi, N., Takarada, T., Yoneda, Y.
  • Journal Title: J. Pharmacol. Sci. 110(2) Pages: 133-149
  • Peer Reviewed
• [Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus (2009)
  • Author(s): Takeshi Takarada, et al.
  • Journal Title: Journal of Neurochemistry 110(5) Pages: 1457-1468
  • Peer Reviewed
• [Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism (2009)
  • Author(s): Noritaka Nakamichi, et al.
  • Journal Title: Journal of Neuroscience Research 87(11) Pages: 2406-2417
  • Peer Reviewed
• [Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly (2009)
  • Author(s): Bin Gu, et al.
  • Journal Title: Journal of Neuroscience Research 87(9) Pages: 2145-2156
  • Peer Reviewed
• [Journal Article] Neurogenesis mediated by GABA and glutamate signaling (2009)
  • Author(s): Noritaka Nakamichi, et al.
  • Journal Title: Journal of Pharmacological Sciences 110(2) Pages: 133-149
  • Peer Reviewed
• [Journal Article] Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells. (2008)
  • Author(s): Nakamichi, N., Yoshida, K., Ishioka, Y., Makanga, J.O., Fukui, M., Yoneyama, M., Kitayama, T.
  • Journal Title: J. Neurochem. 105(5) Pages: 1996-2012
  • Peer Reviewed
• [Journal Article] Yoneda, Y.: Upregulation of ciliary neurotrophic factor expression by GABAA receptors in undifferentiated neural progenitors of fetal mouse brain. (2008)
  • Author(s): Fukui, M., Nakamichi, N., Yoneyama, M., Yoshida, K., Ozawa, S., Kitayama, T., Nakamura, N., Taniura, H.
  • Journal Title: J. Neurosci. Res. 86(12) Pages: 2615-2623
  • Peer Reviewed
• [Journal Article] Insensitivity to glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors in association with delayed mitochondrial membrane potential disruption in cultured rat cortical neurons. (2008)
  • Author(s): Kambe, Y., Nakamichi, N., Georgiev, D.D., Nakamura, N., Taniura, H., Yoneda, Y.
  • Journal Title: J. Neurochem. 105(5) Pages: 1886-1900
  • Peer Reviewed
• [Journal Article] Promotion of neuronal differentiation through activation of NMDA receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex. (2008)
  • Author(s): Yoneyama, M., Nakamichi, N., Fukui, M., Kitayama, T., Georgiev, D.D., Makanga, J.O., Nakamura, N., Taniura, H., Yoneda, Y.
  • Journal Title: J. Neurosci. Res 86(11) Pages: 2392-2402
  • Peer Reviewed
• [Journal Article] Modulation of cellular proliferation and differentiation through GABAB receptors expressed by undifferentiated neural progenitor cells isolated from fetal mouse brain. (2008)
  • Author(s): Fukui, M., Nakamichi, N., Yoneyama, M., Ozawa, S., Fujimori, S., Takahata, Y., Nakamura, N., Taniura, H., Yoneda, Y.
  • Journal Title: J. Cell. Physiol. 216(2) Pages: 507-519
  • Peer Reviewed
• [Journal Article] Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience (2008)
  • Author(s): Keisuke Tamaki, et.al.
  • Journal Title: Journal of Neurochemistry 105(5) Pages: 1642-1655
  • Peer Reviewed
• [Journal Article] Insensitivity to glutamate neurotoxicity mediated by NMDA receptors in association with delayed mitochondrial membrane potential disruption in cultured rat corticalneurons (2008)
  • Author(s): Yuki Kambe, et.al.
  • Journal Title: Journal of Neurochemistry 105(5) Pages: 1886-1900
  • Peer Reviewed
• [Journal Article] Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells (2008)
  • Author(s): Noritaka Nakamichi, et.al.
  • Journal Title: Journal of Neurochemistry 105(5) Pages: 1996-2012
  • Peer Reviewed
• [Journal Article] Modulation of cellular proliferation and differentiation through GABAB receptors expressed by undifferentiated neural progenitor cells isolated from fetal mouse brain (2008)
  • Author(s): Masaki Fukui, et.al.
  • Journal Title: Journal of Cellular Physiology 216(2) Pages: 507-519
  • Peer Reviewed
• [Journal Article] Promotion of neuronal differentiation through activation of N-methyl-D-aspartate receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex (2008)
  • Author(s): Masanori Yoneyama, et.al.
  • Journal Title: Journal of Neuroscience Research 86(11) Pages: 2392-2402
  • Peer Reviewed
• [Journal Article] Up-regulation of ciliary neurotrophic factor receptor expression by GABA_A receptors in undifferentiated neural progenitors of fetal mouse brain (2008)
  • Author(s): Masaki Fukui, et.al.
  • Journal Title: Journal of Neuroscience Research 86(12) Pages: 2615-2623
  • Peer Reviewed
• [Presentation] グリア細胞におけるグルタミントランスポーターの細胞内局在 (2010)
  • Author(s): 佐古彩, 小椋正人, 中道範隆, 宝田剛志, 米田幸雄
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] マウスにおけるカルニチン/有機カチオントランスポーターの機能的発現 (2010)
  • Author(s): 中道範隆, 杉浦智子, 田口貴之, 清水 卓也, 若山友彦, 井関尚一, 辻彰, 加藤将夫
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] 止潟薬成分のNR2Bサブユニット選択性 (2010)
  • Author(s): 北島聖也, et al.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] NMDA神経毒性に対するATPの保護作用 (2010)
  • Author(s): 高田紗矢, et al.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] 神経細胞新生に対する静磁場の促進作用 (2010)
  • Author(s): 中里亮太, et al.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] 田七人参成分のグルタミン酸神経毒性保護作用 (2010)
  • Author(s): 藤田弘幸, et al.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] 新規血小板増加薬Eltrombopagの体内生態と肝取り込み機構 (2010)
  • Author(s): 竹内和也, et al.
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山大学/就実大学(岡山)
• [Presentation] Functional expression of carnitine/organic cation transporter OCTN1 (SLC22A4) in mouse small intestine. (2009)
  • Author(s): Shimizu, T., Sugiura, T., Nakamichi, N., Wakayama, T., Iseki, S., Kubo, Y., Tamai, I., Tsuji, A., Kato, Y.
  • Organizer: 日本薬物動態学会第24回年会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] Suppression by myosion VI of neural progenitor proliferation. (2009)
  • Author(s): Nakamichi, N., Yoneda, Y.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Glutamine transporter expressed by glial cells in glutamate neurotoxicity. (2009)
  • Author(s): Iemata, M., Ogura, M., Taniura, H., Nakamichi, N., Takarada, T., Yoneda, Y.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] アストログリア細胞に発現するグルタミントランスポーターによるグルタミン酸神経毒性防御 (2009)
  • Author(s): 家亦美佳, 小椋正人, 谷浦秀夫, 中道 範隆, 宝田剛志, 米田幸雄
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 会, 伊香保温泉ホテル天坊(群馬)
• [Presentation] グリア細胞に発現するグルタミントランスポーターのグルタミン酸神経毒性における役割 (2009)
  • Author(s): 小椋正人, 谷浦秀夫, 中道範隆, 米田 幸雄
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] アストログリア細胞に発現するグルタミントランスポーターによるグルタミン酸神経毒性防御 (2009)
  • Author(s): 家亦美佳, et al.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天坊(群馬)
• [Presentation] トラウマ性ストレス応答性を示すミオシンVIによる神経系前駆細胞の増殖抑制 (2009)
  • Author(s): 伊東佑真, et al.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天坊(群馬)
• [Presentation] ニコチン曝露アストログリアにおけるグリア由来神経栄養因子の生成促進 (2009)
  • Author(s): 川越博文, et al.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天坊(群馬)
• [Presentation] 中大脳動脈結紮マウス脳内におけるIfrdl mRNA発現の一過性上昇 (2009)
  • Author(s): 小西志歩, et al.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天坊(群馬)
• [Presentation] 神経細胞に発現する鉄関連遺伝子 (2009)
  • Author(s): 中村有加里, et al.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天坊(群馬)
• [Presentation] NMDA受容体強制発現HEK293細胞株の機能解析 (2009)
  • Author(s): 福森良, et al.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉 ホテル天坊(群馬)
• [Presentation] Suppression by myosion VI of neural progenitor proliferation (2009)
  • Author(s): Nakamichi, N., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Predominant expression of IFRDI by neural progenitor cells in adult mouse hippocampus (2009)
  • Author(s): Konishi, S., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Promotion of astroglial differentiation by group III metabotropic glutamate receptors in murine neural progenitor cells (2009)
  • Author(s): Makanga, J.O., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Myosin VI expression in response to traumatic stress in murine hippocampus (2009)
  • Author(s): Tachibana.M., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Neuroprotection by ATP against NMDA toxicity (2009)
  • Author(s): Kodama, A., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Iron-related genes expressed in brain (2009)
  • Author(s): Nakamura, Y., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Glutamine transporter expressed by glial cells in glutamate neurotoxicity (2009)
  • Author(s): Iemata, M., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Transactivation of glia-derived neurotrophic factor by nicotine in cultured rat cortical astrocytes (2009)
  • Author(s): Kawagoe, H., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Down-regulation of glutamate transporter expression by lipopolysaccharide in cultured astrocytes (2009)
  • Author(s): Nakamura, Y., et al.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] Functional expression of carnitine/organic cation transporter OCTNI (SLC22A4) in mouse small intestine (2009)
  • Author(s): Takuya Shimizu, et al.
  • Organizer: 日本薬物動態学会第24回年会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] Small GTP-binding protein Rab8 regulates the intestinal absorption of substrates for SLC influx transporters (PEPTI.SGLTI) in vivo (2009)
  • Author(s): Tomoko Sugiura, et al.
  • Organizer: 日本薬物動態学会第24回年会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] PDZKI and Rab8 deficient mice are useful tools for analysis of transporter-mediated intestinal drug absorption in vivo (2009)
  • Author(s): Tomoko Sugiura, et al.
  • Organizer: 第31回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 大阪大学コンベンションセンター(大阪)
• [Presentation] グリア細胞に発現するグルタミントランスポーターのグルタミン酸神経毒性における役割 (2009)
  • Author(s): 小椋正人, et.al.
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] NMDA神経毒性に対するミトコンドリアカルシウム流入の関与 (2009)
  • Author(s): 神戸悠輝, et.al.
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] PTSD発症に関与する遺伝子Myo6の発現 (2009)
  • Author(s): 伊東佑真, et.al.
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] アストログリア細胞に発現するニコチン受容体 (2009)
  • Author(s): 川越博文, et.al.
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] マウス中大脳動脈結紮モデルの作製 (2009)
  • Author(s): 小西志歩, et.al.
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] 鉄関連遺伝子の神経細胞における発現 (2009)
  • Author(s): 中村有加里, et.al.
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] HEK293細胞における機能的NMDA受容体の強制発現 (2009)
  • Author(s): 福森良, et.al.
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] グループIII型mGluRによる神経系前駆細胞の機能制御 (2009)
  • Author(s): Juliet_O. Makanga, et.al.
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] グルタミントランスポーターによる酸化的ストレス感受性の決定機構 (2008)
  • Author(s): 小椋正人, 谷浦秀夫, 中道範隆, 米田 幸雄
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸商工会議所(神戸)
  • Year and Date: 2008-11-14
• [Presentation] グルタミントランスポーターによる酸化的ストレス感受性の決定機構 (2008)
  • Author(s): 小椋正人, et.al.
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] GABAシグナルによる未分化神経系前駆細胞の増殖能制御 (2008)
  • Author(s): 小澤秀介, et.al.
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] 培養神経細胞におけるNMDA神経毒性感受性 (2008)
  • Author(s): 神戸悠輝, et.al.
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] 神経系前駆細胞の分化能決定に関連する特定遺伝子 (2008)
  • Author(s): 前田紗弥香, et.al.
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] グループIII代謝調節型グルタミン酸レセプターシグナルによる神経系前駆細胞制御 (2008)
  • Author(s): Juliet O. Makanga, et.al.
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] ラットアストログリア細胞に発現するグルタミントランスポーターは酸化的ストレス感受性を調節する (2008)
  • Author(s): 小椋正人, 福森良, 伊東佑真, 中道範隆, 谷浦秀夫, 米田幸雄
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 品川プリンスホテル(東京)
• [Presentation] アストログリア細胞に発現するグルタミントランスポーターは酸化的ストレス脆弱性決定因子である (2008)
  • Author(s): 小椋正人, 福森良, 伊東佑真, 中道範隆, 谷浦秀夫, 米田幸雄
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山国際会議場(富山)
• [Presentation] グルタミン酸神経毒性に対する田七人参含有成分notoginsenoside R1の保護効果 (2008)
  • Author(s): 顧彬, et.al.
  • Organizer: 生体機能と創薬シンポジウム2008
  • Place of Presentation: 東京
• [Presentation] アストログリア細胞に発現するグルタミントランスポーターは酸化的ストレス脆弱性決定因子である (2008)
  • Author(s): 小椋正人, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] GABAシグナルによる神経系前駆細胞の増殖と分化の調節 (2008)
  • Author(s): 小澤秀介, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] NMDA神経毒性に対するATPの保護作用 (2008)
  • Author(s): 亀島優太, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] アストロサイトのニコチン性シグナルによる神経細胞保護メカニズム (2008)
  • Author(s): 川越博文, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] 大脳皮質神経細胞のNMDA抵抗性 (2008)
  • Author(s): 神戸悠輝, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] ATPによるアストログリア細胞の神経栄養因子発現制御 (2008)
  • Author(s): 清長大輔, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] 中大脳動脈決紮に伴う脳内グルタメイトレセプターの発現変化 (2008)
  • Author(s): 黒川晋太郎, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] マウス脳海馬におけるPTSD応答性ミオシンVIの発現 (2008)
  • Author(s): 橘正毅, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] 止瀉薬成分の神経細胞保護作用 (2008)
  • Author(s): 中村有加里, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] 未分化神経系前駆細胞に発現するNMDAレセプターの機能解析 (2008)
  • Author(s): 福森良, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] 成熟脳海馬神経系前駆細胞に高発現するlfrdlの特性 (2008)
  • Author(s): 前田紗弥香, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] グループIII型代謝調節性グルタミン酸レセプターによる神経系前駆細胞の分化制御 (2008)
  • Author(s): Juliet O. Makanga, et.al.
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
• [Presentation] PTSD発症に応答する海馬内遺伝子 (2008)
  • Author(s): 伊東佑真, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会/第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] ラットアストログリア細胞に発現するグルタミントランスポーターは酸化的ストレス感受性を調節する (2008)
  • Author(s): 小椋正人, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会/第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] アストログリア細胞に発現するニコチン受容体 (2008)
  • Author(s): 川越博文, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会/第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] 由来の異なる培養神経細胞におけるNMDA神経毒性 (2008)
  • Author(s): 神戸悠輝, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会/第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] 脳梗塞巣拡大に対する止瀉薬成分の予防効果 (2008)
  • Author(s): 中村有加里, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会/第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Presentation] 神経系前駆細胞の神経細胞への分化脳抑制遺伝子 (2008)
  • Author(s): 前田紗弥香, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会/第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
• [Book] Glutamatergic signaling in neurogenesis.(Maiese K., ed., Neurovascular Medicine) (2009)
  • Author(s): Nakamichi, N., Yoneda, Y.
  • Publisher: Oxford University Press
• [Book] Neurovascular Medicine : Glutamatergic signaling in neurogenesis (2009)
  • Author(s): Noritaka Nakamichi, et.al.
  • Publisher: Oxford University Press