| Project/Area Number |
20790062
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NAKAGAWA Takayuki Kyoto University, 薬学研究科, 准教授 (30303845)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 薬理学 / 精神疾患 / メタンフェタミン / MDMA / 依存性薬物 / 脳切片培養系 / 中脳皮質辺縁ドパミン神経 / 縫線核セロトニン神経 / AMPA受容体 / セロトニン神経感作 / セロトニントランスポーター / シグナル分子 / 抗うつ薬 / ドパミン神経感作 / efflux |
|---|
| Research Abstract |
We found that repeated exposure to various types of abused drugs, such as methamphetamine, cocaine and morphine, commonly induced the augmentation of dopamine release (dopaminergic sensitization) in the rat mesocorticolimbic dopaminergic slice co-cultures. Furthermore, in rat raphe serotonergic slice culture, sustained exposure to MDMA induced marked augmentation of exocytotic serotonin release, which is different from acute MDMA-evoked serotonin efflux.
|
