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Elucidation of regulatory mechanism of B cell activation by the change in sialic acid species

Research Project

Project/Area Number 20790063
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

NAITO Yuko  Kyoto University, 生命科学研究科, 助教 (10456775)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsシアル酸 / B細胞 / 胚中心
Research Abstract

I have reported that major sialic acid species is dramatically changed in activated B cells in germinal centers, the formation of which is triggered by immunization with thymus-dependent (TD) antigen. In this project, I established genetically modified mice that were expected to cancel the activation-dependent change in sialic acid species, and analyzed B cell phenotypes of these mice. Since these mice formed germinal centers upon TD antigen immunization, I examined antibody production in TD response.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008

All Journal Article (2 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Activation-dependent change in sialic acid species in mouse B cells(マウスB細胞の活性化に伴うシアル酸分子種の変化)2009

    • Author(s)
      内藤裕子
    • Journal Title

      Trends in GLycoscience and Glycotechnology 21巻

      Pages: 237-246

    • Related Report
      2009 Final Research Report
  • [Journal Article] Activation-dependent change in sialic acid species in mouse B cells(マウスB細胞の活性化に伴うシアル酸分子種の変化)2009

    • Author(s)
      内藤裕子
    • Journal Title

      Trends in Glycoscience and Glycotechnology 21

      Pages: 237-246

    • Related Report
      2009 Annual Research Report
  • [Presentation] N-glycolylneuraminic acid-mediated regulation of lymphocyte activation2009

    • Author(s)
      内藤裕子、竹松弘、村田恵祐、小堤保則
    • Organizer
      CREST International Symposium「Acquired Immunity and Glycobiology」
    • Place of Presentation
      Kazusa Akademia Hall(千葉)
    • Year and Date
      2009-03-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Exploration of functional significance of the activation-dependent repression of N-glycolylneuraminic acid in mouse lymphocytes2008

    • Author(s)
      内藤裕子、竹松弘、村田恵祐、小堤保則
    • Organizer
      International Symposium on Systems Glycobiology
    • Place of Presentation
      Tokyo Conference Center(東京)
    • Year and Date
      2008-12-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Activation-dependent repression of N-glycolylneuraminic acid in mouse B- and T-lymphocytes2008

    • Author(s)
      内藤裕子
    • Organizer
      2008 Annual Conference of the Society for Glycobiology
    • Place of Presentation
      Fort Worth(Texas, USA)
    • Year and Date
      2008-11-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Activation-dependent repression of N-glycolylneuraminic acid in mouse B- and T-lymphocytes2008

    • Author(s)
      内藤裕子
    • Organizer
      2008 Annual Conference of the Society for Glycobiology
    • Place of Presentation
      Fort Worth, Texas, USA
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Book] 糖鎖情報の独自性と普遍性「B細胞の機能調節における糖鎖認識の重要性-B細胞活性化に伴う糖鎖の変化-」2008

    • Author(s)
      内藤裕子、竹松弘、小堤保則
    • Publisher
      共立出版
    • Related Report
      2009 Final Research Report
  • [Book] 糖鎖情報の独自性と普遍性(一部)2008

    • Author(s)
      内藤裕子、竹松弘、小堤保則
    • Total Pages
      298
    • Publisher
      共立出版
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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