Elucidation of regulatory mechanism of B cell activation by the change in sialic acid species

• Project/Area Number: 20790063
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: NAITO Yuko Kyoto University, 生命科学研究科, 助教 (10456775)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: シアル酸 / B細胞 / 胚中心

Research Abstract

I have reported that major sialic acid species is dramatically changed in activated B cells in germinal centers, the formation of which is triggered by immunization with thymus-dependent (TD) antigen. In this project, I established genetically modified mice that were expected to cancel the activation-dependent change in sialic acid species, and analyzed B cell phenotypes of these mice. Since these mice formed germinal centers upon TD antigen immunization, I examined antibody production in TD response.

Research Products

• [Journal Article] Activation-dependent change in sialic acid species in mouse B cells(マウスB細胞の活性化に伴うシアル酸分子種の変化) (2009)
  • Author(s): 内藤裕子
  • Journal Title: Trends in GLycoscience and Glycotechnology 21巻 Pages: 237-246
• [Journal Article] Activation-dependent change in sialic acid species in mouse B cells(マウスB細胞の活性化に伴うシアル酸分子種の変化) (2009)
  • Author(s): 内藤裕子
  • Journal Title: Trends in Glycoscience and Glycotechnology 21 Pages: 237-246
• [Presentation] N-glycolylneuraminic acid-mediated regulation of lymphocyte activation (2009)
  • Author(s): 内藤裕子、竹松弘、村田恵祐、小堤保則
  • Organizer: CREST International Symposium「Acquired Immunity and Glycobiology」
  • Place of Presentation: Kazusa Akademia Hall(千葉)
  • Year and Date: 2009-03-24
• [Presentation] Exploration of functional significance of the activation-dependent repression of N-glycolylneuraminic acid in mouse lymphocytes (2008)
  • Author(s): 内藤裕子、竹松弘、村田恵祐、小堤保則
  • Organizer: International Symposium on Systems Glycobiology
  • Place of Presentation: Tokyo Conference Center(東京)
  • Year and Date: 2008-12-05
• [Presentation] Activation-dependent repression of N-glycolylneuraminic acid in mouse B- and T-lymphocytes (2008)
  • Author(s): 内藤裕子
  • Organizer: 2008 Annual Conference of the Society for Glycobiology
  • Place of Presentation: Fort Worth(Texas, USA)
  • Year and Date: 2008-11-14
• [Presentation] Activation-dependent repression of N-glycolylneuraminic acid in mouse B- and T-lymphocytes (2008)
  • Author(s): 内藤裕子
  • Organizer: 2008 Annual Conference of the Society for Glycobiology
  • Place of Presentation: Fort Worth, Texas, USA
  • Year and Date: 2008-11-14
• [Book] 糖鎖情報の独自性と普遍性「B細胞の機能調節における糖鎖認識の重要性-B細胞活性化に伴う糖鎖の変化-」 (2008)
  • Author(s): 内藤裕子、竹松弘、小堤保則
  • Publisher: 共立出版
• [Book] 糖鎖情報の独自性と普遍性(一部) (2008)
  • Author(s): 内藤裕子、竹松弘、小堤保則
  • Total Pages: 298
  • Publisher: 共立出版