Elucidation of regulatory mechanism of B cell activation by the change in sialic acid species
| Project/Area Number |
20790063
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
NAITO Yuko Kyoto University, 生命科学研究科, 助教 (10456775)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | シアル酸 / B細胞 / 胚中心 |
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| Research Abstract |
I have reported that major sialic acid species is dramatically changed in activated B cells in germinal centers, the formation of which is triggered by immunization with thymus-dependent (TD) antigen. In this project, I established genetically modified mice that were expected to cancel the activation-dependent change in sialic acid species, and analyzed B cell phenotypes of these mice. Since these mice formed germinal centers upon TD antigen immunization, I examined antibody production in TD response.
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Report
(3 results)
Research Products
(8 results)
