| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Reelin is a secreted protein essential for brain development. We analyzed when and where Reelin acts in developing forbrain. Functional Receptors are mainly present at newborn neurons, and they are downregulated at postmigrating neurons. We further identified some kinds of glycoproteins as candidate binding factor of Reelin at the extracellular milieu. These results suggest that Reelin protein is not merely a diffusive molecule, but also is affected by extracellular matrices or by acceptor cells.
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