Functional analyses of fad104 on survival just after birth and insulin sensitivity.

• Project/Area Number: 20790070
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: NISHIZUKA Makoto Nagoya City University, 大学院・薬学研究科, 講師 (00363953)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肥満 / 糖尿病 / 脂肪細胞分化 / 新生児疾患 / 遺伝子発現 / 肺形成 / fad104 / 新生児 / ノックアウトマウス / サーファクタント / インスリン感受性

Research Abstract

In this study, we demonstrated that fad104, a positive regulator of adipogenesis, has a crucial role for regulating the formation of white adipose tissue and insulin sensitivity. Furthermore, we also demonstrated that fad104 is essential for lung development just after birth.

Research Products

• [Journal Article] Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation. (2010)
  • Author(s): Kishimoto K., Kato A., Osada S., Nishizuka M., Imagawa M.
  • Journal Title: Biochem. Biophys. Res. Commun. (in press)
  • Peer Reviewed
• [Journal Article] TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion. (2010)
  • Author(s): Kawaji A., Nishizuka M., Osada S., Imagawa M.
  • Journal Title: Biol.Pharm.Bull. 33(3) Pages: 404-409
  • Peer Reviewed
• [Journal Article] Gelsolin, an actin regulatory protein, is required for differentiation of mouse 3T3-L1 cells into adipocytes. (2010)
  • Author(s): Kawaji A., Ohnaka Y., Osada S., Nishizuka M.,Imagawa M
  • Journal Title: Biol.Pharm.Bull. 33(5) Pages: 773-779
  • NAID: 130000248035
  • Peer Reviewed
• [Journal Article] The role of C/EBPdelta in the early stages of adipogenesis. (2009)
  • Author(s): Hishida T., Nishizuka M., Osada S., Imagawa M
  • Journal Title: Biochimie 91(5) Pages: 654-657
  • Peer Reviewed
• [Journal Article] Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion (2009)
  • Author(s): Nishizuka M., Kishimoto K., Kato A., Ikawa, M., Okabe, M., Sato R., Niida H., Nakanishi M., Osada S., Imagawa M.
  • Journal Title: spreading and migration Exp. Cell Res. 315(5) Pages: 809-819
  • Peer Reviewed
• [Journal Article] Disruption of the novel gene fadl04 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration (2009)
  • Author(s): Nishizuka M., Kishimoto K., Kato A., Ikawa M., Okabe M., Sato R., Niida H., Nakanishi M., Osada S. and Imagawa M.
  • Journal Title: Experimental Cell Research 315(5) Pages: 809-819
  • Peer Reviewed
• [Journal Article] A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion. (2008)
  • Author(s): Hishida T., Eguchi T., Osada S., Nishizuka M., Imagawa M.
  • Journal Title: FEBS J. 275(22) Pages: 5576-5588
  • Peer Reviewed
• [Journal Article] Wnt4 and Wnt5a promote adipocyte differentiation. (2008)
  • Author(s): Nishizuka M., Koyanagi A., Osada S., Imagawa M.
  • Journal Title: FEBS Lett. 582(21-22) Pages: 3201-3205
  • Peer Reviewed
• [Journal Article] Wnt4 and Wnt5a promote adipocyte differentiation (2008)
  • Author(s): Nishizuka M., Koyanagi A., Osada S. and Imagawa M
  • Journal Title: FEBS Letter 582(21-22) Pages: 3201-3205
  • Peer Reviewed
• [Journal Article] A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion (2008)
  • Author(s): Hishida T., Eguchi T., Osada S., Nishizuka M. and Imagawa M
  • Journal Title: FEBS Journal 275(22) Pages: 5576-5588
  • Peer Reviewed
• [Presentation] 肺形成におけるfad104の機能解析 (2010)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Mouse embryonic fibroblasts (MEF)を用いたfad104の機能解析 (2009)
  • Author(s): 加藤愛友美、岸本圭史、長田茂宏、西塚誠、今川正良
  • Organizer: 日本病院薬剤師会東海ブロック、日本薬学会東海支部合同学術大会2009
  • Place of Presentation: 四日市
  • Year and Date: 2009-11-23
• [Presentation] 脂肪細胞分化に重要であるfad104の肺発生における役割 (2009)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: 第8回次世代を担う若手ファーマ・バイオフォーラム2009
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-14
• [Presentation] 脂肪細胞分化に重要なfad104は出生直後の生命維持に必須である (2009)
  • Author(s): 岸本圭史、西塚誠、加藤愛友美、長田茂宏、今川正良
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] Masayoshi Imagawa Heterozygous knockout of fad104 gene reduces body weight gain and increase glucose metabolism (2009)
  • Author(s): Makoto Nishizuka, Junko Kako, Keishi Kishimoto, Shigehiro Osada
  • Organizer: 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 上海
  • Year and Date: 2009-08-05
• [Presentation] Masayoshi Imagawa The novel gene fad104 is indispensable for lung development and is crucial role for cell proliferation, adhesion, migration and cytoskeletal organization. (2009)
  • Author(s): Keishi Kishimoto, Makoto Nishizuka, Ayumi Kato, Shigehiro Osada
  • Organizer: 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 上海
  • Year and Date: 2009-08-05
• [Presentation] The novel gene fad104 is indispensable for lung development and is crucial role for cell proliferation, adhesion, migration and cytoskeletal organization (2009)
  • Author(s): Kishimoto K., Nishizuka M., Kato A., Osada S., Imagawa M.
  • Organizer: 21^<st> IUBMB ang 12^<th> FAOBLMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 上海
  • Year and Date: 2009-08-05
• [Presentation] Heterozygous knockout of fad104 gene reduces body weight gain and in crease glucose metabolism (2009)
  • Author(s): Makoto Nishizuka, Junko Kako, Keishi Kishimoto, Shigehiro Osada, Masayopshi Imagawa
  • Organizer: 21^<st> IUBMB ang 12^<th> FAOBLMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 上海
  • Year and Date: 2009-08-05
• [Presentation] fad104ヘテロ欠損は体重増加ならびにインスリン抵抗性を抑制する (2009)
  • Author(s): 西塚誠、加子順子、岸本圭史、長田茂宏、今川正良
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] 脂肪細胞分化および出生直後の生命機能維持に必須であるfad104の機能解析 (2009)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] 脂肪細胞分化を促進するfad104が糖代謝能ならびにインスリン感受性に与える影響の解析 (2008)
  • Author(s): 西塚誠、加子順子、岸本圭史、長田茂宏、今川正良
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] 脂肪細胞分化に重要であるfad104欠損MEF(mouse embryo fibroblasts)の性状解析 (2008)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] 脂肪細胞分化に重要であるfad104欠損MEF (mouse embryo fibroblasts)の性状解析 (2008)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 良新規遺伝子fad104欠損MEF (mouse embryo fibroblasts)の性状解析 (2008)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正
  • Organizer: ファーマバイオフォーラム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-11-30
• [Presentation] 新規遺伝子fad104欠損MEF(mouse embryo fibroblasts)の性状解析 (2008)
  • Author(s): 岸本圭史、西塚誠、長田茂宏、今川正良
  • Organizer: ファーマバイオフォーラム2008
  • Place of Presentation: 東京
  • Year and Date: 2008-11-30