| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
HAF-2, which is one of the nematode homologues of human lysosomal ABC (ATP-binding cassette) transporter, is expressed in neuronal cells, muscles, some of intestinal cells, and coelomocytes in Caenorhabdits elegans. We found that at least in coelomocytes, HAF-2 localizes on the lysosome-related granules and is not essential for the uptake of foreign substances. HAF-2 was also expressed in neuronal cells including amphid and phasmid sensory neurons. The deletion for the haf-2 gene showed the slight defects in growth rate, lifespan, brood size, defecation rate, and so on, suggesting that the intracellular lysosomal transporter is involved in the various physiological aspects at the organismal level.
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