| Project/Area Number |
20790074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
ITOU Masaaki Takasaki University of Health and Welfare, 薬学部, 助教 (30438759)
|
|---|
| Research Collaborator |
MATSUOKA Isao 高崎健康福祉大学, 薬学部, 教授 (10145633)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞外ヌクレオチド / プリン受容体 / マクロファージ / プロスタグランジン / 細胞内情報伝達 / 炎症反応 |
|---|
| Research Abstract |
We have shown a new inhibitory mechanism against inflammatory response to extracellular nucleotides-induced Gq protein/phospholipase C (PLC) pathway. Because the Gq/PLC pathway consolidates several signal transductions caused by hormones and neurotransmitters, inhibition of this pathway may be an attractive target for novel therapeutic drugs.
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