Antinociceptive and side effects of novel oral active indole alkaloids
| Project/Area Number |
20790075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Josai International University |
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Principal Investigator |
MATSUMOTO Kenjiro Josai International University, 薬学部, 助手 (10406770)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | オピオイド / インドールアルカロイド / モルヒネ / ミトラガイニン / 痛み / 経口活性 / オピオイド受容体 / Mitragynine / 抗侵害作用 / μオピオイド受容体 / δオピオイド受容体 |
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| Research Abstract |
本研究ではインドール骨格を基本骨格とする7-hydroxymitragynine(7-OHMG)関連化合物の鎮痛活性の評価、副作用の検討、作用機序解析を行った。我々の検討により、強力な鎮痛活性と低い副作用特性を合わせ持つMGM-9やモルヒネより約45倍強力な鎮痛活性を有する化合物MGM-16等が発見された。またMitragynine関連化合物について国内、米国、国際特許出願を行った。
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting mu- and kappa-opioid agonist with potent antinociceptive and weak rewarding effects in mice2008
Author(s)
松本健次郎, 他11名
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Journal Title
Neuropharmacology 54
Pages: 154-165
Related Report
Peer Reviewed
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[Journal Article] MGM-9[(E)-methyl 2-(3-ethyl-7a, 12a-(epoxyethanoxy)-9-fluoro-1, 2, 3, 4, 6, 7, 12, 12b-octahydro-8- methoxyindolo[2, 3-a]quinolizin-2-y1) -3-methoxyacrylatel, a derivative of the indole alkaloid mitragynine : a novel dual-acting mu- and kappa-opioid agonist with potent antinociceptive and weak rewarding effects in2008
Author(s)
Matsumoto, K.
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Journal Title
Neuropharmacology 54
Pages: 154-165
Related Report
Peer Reviewed
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