| Project/Area Number |
20790078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
ARIMITSU Nagisa Tokyo University of Pharmacy and Life Science, 生命科学部, 助教 (40408688)
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|---|
| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発生生物学 / 遺伝子欠損マウス / 精巣 / 細胞内輸送 / 脂質代謝 |
|---|
| Research Abstract |
Phospholipases of the A1 (PLA1) cleave the sn-1 fatty acyl group from diacyl glycero-phospholipids and produce a free fatty acid and an sn-2-lysophospholipid. The intracellular phospholipase A1 (named iPLA1 from 2009 ) family consists of three members,α,β,γ. To reveal the physiological functions of iPLA1 family member, iPLA1 -β,-γknockout mice(KO)were generated by gene targeting. iPLA1-β and -γKO mice were born and were apparently indistinguishable from wild-type mice. However, male iPLA1-β KO mice were subfertile.
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