| Project/Area Number |
20790079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
MORITA Yuji Aichi Gakuin University, 薬学部, 講師 (00454322)
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| Research Collaborator |
KEITH Poole カナダクィーンズ大学, 微生物部門, 教授
HERBERT Schweizer 米国コロラド州立大学, 微生物学部門, 教授
SANG-JIN Suh 米国Auburn大学, 生物科学部門, 準教授
斉藤 菜摘 慶應義塾大学, 先端生命科学, 講師
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 遺伝子 / 抗生物質 / 細菌 |
|---|
| Research Abstract |
The multidrug efflux system MexXY which is one of major antimicrobial resistant determinants in Pseudomonas aeruginosa is induced via the PA5471 gene product which is inducible by ribosome-targeting antimicrobial agents. A 13-amino-acid open reading frame (PA5471.1) is c.a. 250 bp upstream of the PA5471 coding sequence and its translational repression leads transcriptional inducibility of the PA5471 (or MexXY). The transcriptional termination of the PA5471.1 was implied to be the Rho-factor dependent.
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