| Project/Area Number |
20790084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KISHIMOTO Yasushi Tokushima Bunri University, 香川薬学部, 助教 (90441592)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 瞬目反射条件付け / 運動学習 / 内在性カンナビノイド / 代謝型グルタミン酸受容体 / Tetシステム / 記憶・学習 / 消去 / EVA樹脂 / 2-AG / シナプス可塑性 / 小脳 / 瞬目反射条件づけ / シナプス発達 / イオンチャンネル / 遺伝子改変マウス / 記憶学習 |
|---|
| Research Abstract |
To elucidate the molecular basis of motor learning, three paradigms of eyeblink conditioning (delay, trace and latent inhibition) were investigated by pharmacological treatment and/or genetically-engineered mice. In delay conditioning, endcannnabinoids 2-AG and anandamide are important for memory formation of eyeblink conditioning. Furthermore, this research clearly shown that multiple distinct molecular mechanisms exist for the expression and acquisition during eyeblink conditioning.
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