The role of kinases on multiple G proteins activation by endothelin A receptor
Project/Area Number |
20790086
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Matsuyama University |
Principal Investigator |
HATAE Noriyuki Matsuyama University, 薬学部, 准教授 (30449912)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | プロテインキナーゼC / エンドセリンA受容体 / プロスタグランジン受容体 / G蛋白質 / 細胞内情報伝達 / 脂質ラフト / PKC / 生理活性 / Gq蛋白質 / Gs蛋白質 / シグナル伝達 / 薬学 |
Research Abstract |
G protein coupled receptors, like as endothelin A receptor, are the transmembrane spanning receptors, and the most commonly targeted receptor class for medicinal therapeutics. Agonist binding to the receptor causes them to adopt a conformation that results in the activations of associated multiple heterotrimeric G proteins, but it is still unknown how to selective activated the various G proteins by single receptor. It was clarified the role of protein kinases and lipid rafts on the selective activation of multiple G proteins mediated by receptor.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca^<2+> pathway in a lipid raft-dependent manner.2009
Author(s)
Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N., Tabata, H., Segi-Nishida, E., Tanaka, S., Ichikawa, A., Sugimoto, Y.
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Journal Title
Biochem. Biophys. Res. Commun. 389(4)
Pages: 678-682
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+pathway in a lipid raft-dependent manner2009
Author(s)
Yamaoka K, Yano A, Kuroiwa K, Morimoto K, Inazumi T, Hatae N, Tabata H, Segi-Nishida E, Tanaka S, Ichikawa A, Sugimoto Y.
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Journal Title
Biochem.Biophys.Res.Commun. 389
Pages: 678-682
Related Report
Peer Reviewed
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