| Project/Area Number |
20790089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHIHARA Keiichi The Institute of Physical and Chemical Research, 薬学部, 助教 (80340446)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ダウン症候群 / 神経伝達物質 / マウスモデル / モデルマウス |
|---|
| Research Abstract |
The present study was designed to evaluate at the levels of neurotransmitters in the mouse brain with Down syndrome (DS) that could provide evidence for neurochemical disturbance in the brain of DS patient. Quantification for the contents of various neurotransmitters and their metabolites in the brain of Ts1Cje, a mouse model of DS using HPLC analysis revealed that catabolisms for dopamine and serotonin were enhanced in the Ts1Cje brain. The disturbed catabolisms in Ts1Cje brain were normalized by methamphetamine treatment. Additionally, high expression of catechol-O-methyltransferase (COMT) was detected in the Ts1Cje brain compared to that in wild-type littermates on an immunohistochemical analysis. These findings would be important for clarification of DS pathophysiology, and COMT is expected as a new therapeutic target for the anomalies of DS brain.
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